Caspofungin acetate

Research use only, not for human use.

A lipopeptide antifungal agent that works by inhibiting the enzyme 1,3-beta-glucan synthase and thereby disturbing the integrity of the fungal cell wall.

A lipopeptide antifungal agent that works by inhibiting the enzyme 1,3-beta-glucan synthase and thereby disturbing the integrity of the fungal cell wall.Fungal Infection Approved(In Vitro):Caspofungin diacetate (1-8 mg/kg; i.p.; daily, for 7 days) is able to penetrate the CNS in mice and achieve concentrations that result in the reduction of Candida burden in the brain.Caspofungin diacetate (0.41-41 μM; i.p.; for 5 weeks; male C57BL/6 mice) is a safe antifungal agent at vitreal concentrations of 0.41 to 4.1 μM in mice.

——

Animal Model:Complement component 5-deficient DBA/2N mice Dosage:1, 2, 4 and 8 mg/kg Administration:Intraperitoneal injection; daily, for 7 days Result:Reduced the concentration of Candida load in the brain.Animal Model:Male C57BL/6 mice Dosage:0.41, 1.2, 2.5, 4.1, and 41 μM Administration:Intraperitoneal injection; for 5 weeks Result:Had nonsignificant alterations in their ERG waveforms from 0.41 to 4.1 μM.

L-743872 | L-743873 | MK-0991

Microbiology/Virology

Fungal

1,3-beta-D-glucansynthesis

Infection

Fungal Infection

179463-17-3

1213.417

C56H96N10O19

>98% (HPLC)

H2O: ≥ 100 mg/mL

CC(O)=O.CC(O)=O.CCC(C)CC(C)CCCCCCCCC(=O)NC1CC(O)C(NCCN)NC(=O)C2C(O)CCN2C(=O)C(NC(=O)C(NC(=O)C2CC(O)CN2C(=O)C(NC1=O)C(C)O)C(O)C(O)C1=CC=C(O)C=C1)C(O)CCN

Pneumocandin B0, 1-[(4R,5S)-5-[(2-aminoethyl)amino]-N2-[(10R,12S)-10,12-dimethyl-1-oxotetradecyl]-4-hydroxy-L-ornithine]-5-[(3R)-3-hydroxy-L-ornithine]-, acetate (1:2)

(-20℃)

With Ice Pack

≥ 2 years