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Carbobenzoxyproline

CAS No. 1148-11-4

Carbobenzoxyproline( Benzyloxycarbonylproline,Carbobenzoxy-S-proline )

Catalog No. M22867 CAS No. 1148-11-4

Carbobenzoxyproline is a prolidase inhibitor.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
500MG 35 In Stock
1G 46 In Stock
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Biological Information

  • Product Name
    Carbobenzoxyproline
  • Note
    Research use only, not for human use.
  • Brief Description
    Carbobenzoxyproline is a prolidase inhibitor.
  • Description
    Carbobenzoxyproline is a prolidase inhibitor.
  • In Vitro
    Carbobenzoxyproline (6 mM; 0-10 d; pH=6.0) causes mitochondrial depolarization and increases cellular death by 33% as reported for long-term culture of fibroblasts from prolidase deficiency (PD) patients. Carbobenzoxyproline (0, 1, 3, 6 mM; 1 min; pH=6.0) results fibroblasts prolidase (FBP) hydrolysis, shows linear competitive inhibition.
  • In Vivo
    Carbobenzoxyproline (60 mg/kg; injection; once daily; 3 weeks) serves as in vivo inhibitor of erythrocytes prolidase in mice model. Animal Model:C57Bl/6J mice (4-week-old)Dosage:60 mg/kg Administration:Injection; once daily for 3 weeks Result:Resulted significant reduction of erythrocytes prolidase activity.
  • Synonyms
    Benzyloxycarbonylproline,Carbobenzoxy-S-proline
  • Pathway
    Others
  • Target
    Other Targets
  • Recptor
    prolidase
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    1148-11-4
  • Formula Weight
    249.26
  • Molecular Formula
    C13H15NO4
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO:Soluble
  • SMILES
    C1CC(N(C1)C(=O)OCC2=CC=CC=C2)C(=O)O
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Arkadiusz, Surazynski, and, et al. Prolidase-dependent regulation of TGF c and TGF β receptor expressions in human skin fibroblasts[J]. European Journal of Pharmacology, 2010, 649(1-3):115-119.
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