CYM50358

Research use only, not for human use.

N-(4-(aminomethyl)-2,6-dimethylphenyl)-5 is a potent, selective antagonist of the sphingosine-1-phosphate receptor 4 (S1P4). CYM50358 inhibits S1P4?with an IC50?of 25 nM.

N-(4-(aminomethyl)-2,6-dimethylphenyl)-5 is a potent, selective antagonist of the sphingosine-1-phosphate receptor 4 (S1P4). CYM50358 inhibits S1P4?with an IC50?of 25 nM.(In Vitro):N-(4-(aminomethyl)-2,6-dimethylphenyl)-5 shows less potent inhibition of S1PR1(IC50=6.4μM).N-(4-(aminomethyl)-2,6-dimethylphenyl)-5(10μM)has no effect on the collagen-induced HSP27 phosphorylation,markedly reverses the suppressive effect of S1P on the collagen-induced phospphorylation of HSP27.

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Others

Other Targets

PLD1

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1314212-39-9

389.28

C20H18Cl2N2O2

>98% (HPLC)

In Vitro:?DMSO : 125 mg/mL (321.11 mM)

Cc1cc(CN)cc(C)c1NC(=O)c1ccc(o1)-c1cc(Cl)ccc1Cl

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(-20℃)

With Ice Pack

≥ 2 years