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CYM50260
CAS No. 1355026-60-6
CYM50260( —— )
Catalog No. M23514 CAS No. 1355026-60-6
CYM50260 is an exquisitely agonist of sphingosine-1-phosphate 4 receptor (S1P4-R) (EC50: 45 nM).
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 323 | In Stock |
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| 10MG | 483 | In Stock |
|
| 25MG | 781 | In Stock |
|
| 50MG | 1071 | In Stock |
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| 100MG | 1431 | In Stock |
|
| 200MG | Get Quote | In Stock |
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| 500MG | Get Quote | In Stock |
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| 1G | Get Quote | In Stock |
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Biological Information
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Product NameCYM50260
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NoteResearch use only, not for human use.
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Brief DescriptionCYM50260 is an exquisitely agonist of sphingosine-1-phosphate 4 receptor (S1P4-R) (EC50: 45 nM).
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DescriptionCYM50260 is an exquisitely agonist of sphingosine-1-phosphate 4 receptor (S1P4-R) (EC50: 45 nM). CYM50260 shows no activity against S1P1-R, S1P2-R, S1P3-R and S1P5-R.
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In VitroCYM50260 (Compound 22aa) is a synthetic S1P4-R agonist. CYM50260 is found 3.5-fold more potent than the hit compound (HTS-hit).CYM50260 suppresses the collagen-stimulated platelet aggregation, PDGF-AB secretion and sCD40L release. CYM50260 reduces the release of phosphorylated-HSP27 by collagen as well as the phosphorylation of HSP27.
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In Vivo——
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Synonyms——
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PathwayOthers
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TargetOther Targets
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RecptorS1P4-R
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Research Area——
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Indication——
Chemical Information
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CAS Number1355026-60-6
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Formula Weight350.6
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Molecular FormulaC14H11Cl3FNO2
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 125 mg/mL (356.53 mM)
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SMILESFCC1=CC=C(OCCOC2=CC=C(Cl)C=C2Cl)C(Cl)=N1
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
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D-(-)-Pantolactone
Pantolactone belongs to the class of organic compounds known as gamma-butyrolactones. gamma-Butyrolactones are compounds containing a gamma-butyrolactone moiety which consists of an aliphatic five-member ring with four carbon atoms one oxygen atom and bears a ketone group on the carbon adjacent to the oxygen atom.
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Coumarin 7
Coumarin 7 is a natural product.
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HIF-1 alpha 556-574
HIF-1 alpha (556-574) is a hypoxia-inducible factor-1 19-mer fragment. HIF-1 functions as master regulator of response to oxygen homeostasis. Hypoxia-induced gene expression is initiated when HIF-1subunit is stabilized in response to a lack of oxygen. This part of HIF-1 binds to the von Hippel-Lindau factor (VHL) an E3 ubiquitin ligase, and the proline 564 is absolutely vital to the binding process.
