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CX797
CAS No. 1611496-70-8
CX797( CX-797 | CX 797 )
Catalog No. M12334 CAS No. 1611496-70-8
A potent, specfic CXCR2 antagonist that inhibits IL8 down-regulation of forskolin-induced cAMP with IC50 of 7.79 uM.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
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Biological Information
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Product NameCX797
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NoteResearch use only, not for human use.
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Brief DescriptionA potent, specfic CXCR2 antagonist that inhibits IL8 down-regulation of forskolin-induced cAMP with IC50 of 7.79 uM.
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DescriptionA potent, specfic CXCR2 antagonist that inhibits IL8 down-regulation of forskolin-induced cAMP with IC50 of 7.79 uM; inhibits IL8-mediated cAMP signaling and receptor degradation while specifically up-regulating IL8-mediated β-arrestin-2 recruitment; also inhibits IL8-mediated cell migration.
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In Vitro——
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In Vivo——
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SynonymsCX-797 | CX 797
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PathwayGPCR/G Protein
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TargetChemokine Receptor
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RecptorChemokine Receptor
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Research Area——
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Indication——
Chemical Information
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CAS Number1611496-70-8
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Formula Weight382.5
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Molecular FormulaC19H18N4OS2
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Purity>98% (HPLC)
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Solubility——
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SMILESCC1CCCC2=C1C3=C(S2)N4C(=NN=C4SC)N(C3=O)C5=CC=CC=C5
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Chemical Name(R)-6-methyl-1-(methylthio)-4-phenyl-6,7,8,9-tetrahydrobenzo[4,5]thieno[3,2-e][1,2,4]triazolo[4,3-a]pyrimidin-5(4H)-one
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Ha H, et al. Mol Pharm. 2014 Jul 7;11(7):2431-41.
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