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CPUY074020
CAS No. 902279-44-1
CPUY074020( —— )
Catalog No. M32863 CAS No. 902279-44-1
CPUY074020 is a potent and orally bioavailable inhibitor of histone methyltransferase G9a (IC50: 2.18 μM) with anti-proliferative activity.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 172 | Get Quote |
|
| 5MG | 250 | Get Quote |
|
| 10MG | 359 | Get Quote |
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| 25MG | 545 | Get Quote |
|
| 50MG | 766 | Get Quote |
|
| 100MG | 981 | Get Quote |
|
| 200MG | 1341 | Get Quote |
|
| 500MG | Get Quote | Get Quote |
|
| 1G | Get Quote | Get Quote |
|
Biological Information
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Product NameCPUY074020
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NoteResearch use only, not for human use.
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Brief DescriptionCPUY074020 is a potent and orally bioavailable inhibitor of histone methyltransferase G9a (IC50: 2.18 μM) with anti-proliferative activity.
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DescriptionCPUY074020 is a potent and oral bioavailable inhibitor of histone methyltransferase G9a, with an IC50 of 2.18 μM. CPUY074020 possesses anti-proliferative activity.
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In VitroCPUY074020 (2-8μM; 24 hours) induces cell death through apoptosis.CPUY074020 (2.5-10μM ; 48 hours) dose-dependently de-regulates H3K9 trimethylation.Apoptosis Analysis Cell Line:MCF-7 cells Concentration:2 μM, 4 μM, 8 μM Incubation Time:24 hours Result:Induced MCF-7 cells apoptosis.Western Blot Analysis Cell Line: MCF-7 cells Concentration:2.5 μM, 5 μM, 10 μM Incubation Time:48 hours Result:Dose-dependently de-regulated H3K9 trimethylation.
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In VivoCPUY074020 exhibits reasonable PK properties, with an oral bioavailability of 55.5% and a T1/2 value of 4.0 hours at an oral dose of 10 mg/kg.Animal Model:Mice Dosage:10 mg/kg Administration:Oral administration Result:t1/2=4.0 hours
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Synonyms——
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PathwayOthers
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TargetOther Targets
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RecptorHistone Methyltransferase
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Research Area——
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Indication——
Chemical Information
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CAS Number902279-44-1
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Formula Weight416.52
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Molecular FormulaC25H28N4O2
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Purity>98% (HPLC)
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Solubility——
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SMILESN(CCN1CCCC1)C2=C3C=4C(C(=C2)N5CCCCC5)=NOC4C=6C(C3=O)=CC=CC6
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Chen WL, et al. Discovery, design and synthesis of 6H-anthra[1,9-cd]isoxazol-6-one scaffold as G9a inhibitor through a combination of shape-based virtual screening and structure-based molecular. Bioorg Med Chem. 2016 Nov 15;24(22):6102-6108.?
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