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CHMFL-ABL-121
CAS No. 2270879-07-5
CHMFL-ABL-121( —— )
Catalog No. M26111 CAS No. 2270879-07-5
CHMFL-ABL-121 is a highly potent inhibitor of type II ABL kinase.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 264 | Get Quote |
|
| 5MG | 403 | Get Quote |
|
| 10MG | 592 | Get Quote |
|
| 25MG | 888 | Get Quote |
|
| 50MG | 1242 | Get Quote |
|
| 100MG | 1701 | Get Quote |
|
| 500MG | 3402 | Get Quote |
|
| 1G | Get Quote | Get Quote |
|
Biological Information
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Product NameCHMFL-ABL-121
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NoteResearch use only, not for human use.
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Brief DescriptionCHMFL-ABL-121 is a highly potent inhibitor of type II ABL kinase.
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DescriptionCHMFL-ABL-121 is a highly potent inhibitor of type II ABL kinase (IC50s: 2 nM and 0.2 nM against purified inactive ABL wt and T315I kinase protein).(In Vitro):CHMFL-ABL-121 induces apoptosis and arrests the cell cycle at the G0/G1 phase. CHMFL-ABL-121 dose-dependently inhibits BCRABL's auto-phosphorylation at the Y245 site in MEG-01 (EC50<10 nM), K562 (EC50<10 nM), and KU812 (EC50<30 nM) cells and also significantly blocks the phosphorylation of downstream signaling mediators STAT5, CrkL, and ErK.
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In VitroCHMFL-ABL-121 dose-dependently inhibits BCRABL's auto-phosphorylation at Y245 site in K562 (EC50<10 nM),MEG-01 (EC50<10 nM) and KU812 (EC50<30 nM) cells and also significantly blocks the phosphorylation of downstream signaling mediators STAT5, CrkL and ErK.CHMFL-ABL-121 induces apoptosis and arrests cell cycle at G0/G1 phase.
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In Vivo——
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Synonyms——
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PathwayAngiogenesis
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TargetBcr-Abl
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Recptor——
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Research Area——
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Indication——
Chemical Information
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CAS Number2270879-07-5
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Formula Weight580.67
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Molecular FormulaC30H31F3N6OS
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Purity>98% (HPLC)
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Solubility——
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SMILESCN1CCN(Cc2ccc(NC(=O)CCSc3ccc4c(\C=C\c5ccccn5)n[nH]c4c3)cc2C(F)(F)F)CC1
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Ortega C, et al. Fast analysis of important wine volatile compounds development and validation of a new method based on gas chromatographic-flame ionisation detection analysis of dichloromethane microextracts. J Chromatogr A. 2001 Jul 20;923(1-2):205-14.
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