Cart
sales@molnova.com
Home - Products - Others - Other Targets - CGP37157

CGP37157

CAS No. 75450-34-9

CGP37157( 7-Chloro-5-(2-chlorophenyl)-1,5-dihydro-4,1-benzothiazepine-2(3H)-one )

Catalog No. M26645 CAS No. 75450-34-9

CGP37157 is a Na+/Ca2+ exchanger inhibitor, inhibits Na+-induced Ca2+ release from mitochondria in guinea pig heart with IC50 of 0.8 μM.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
5MG 41 Get Quote
10MG 69 Get Quote
25MG 140 Get Quote
50MG 235 Get Quote
100MG 400 Get Quote
200MG Get Quote Get Quote
500MG Get Quote Get Quote
1G Get Quote Get Quote
Get Quotation Bulk Inquiry Add to Cart

Biological Information

  • Product Name
    CGP37157
  • Note
    Research use only, not for human use.
  • Brief Description
    CGP37157 is a Na+/Ca2+ exchanger inhibitor, inhibits Na+-induced Ca2+ release from mitochondria in guinea pig heart with IC50 of 0.8 μM.
  • Description
    CGP37157 is a Na+/Ca2+ exchanger inhibitor, inhibits Na+-induced Ca2+ release from mitochondria in guinea pig heart with IC50 of 0.8 μM.(In Vitro):Administration of 10?μM CGP37157 shows an inhibitory effect on mitochondrial Na+/Ca2+ exchanger in cortical neurons, modulating intracellular Ca2+ levels via suppressing voltage-gated calcium channels. Administration of 10?μM CGP37157 in combination with salinomycin significantly attenuates cell viability and increases apoptosis of FaDu and HLaC79 cells. CGP37157 has no inhibitory effect on salinomycin tumor toxicity. Administration of 10?μM CGP37157 reduces NMDA-induced cytosolic and mitochondrial Ca2+ overloads and it also reduces NMDA-induced excitotoxicity, and such an effect is via attenuating mitochondrial damage and calpain activity in neurons.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    7-Chloro-5-(2-chlorophenyl)-1,5-dihydro-4,1-benzothiazepine-2(3H)-one
  • Pathway
    Others
  • Target
    Other Targets
  • Recptor
    ——
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    75450-34-9
  • Formula Weight
    324.22
  • Molecular Formula
    C15H11Cl2NOS
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : ≥ 125 mg/mL (385.54 mM)
  • SMILES
    Clc1ccc2NC(=O)CSC(c3ccccc3Cl)c2c1
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Svitkin YV, et al. N1-methyl-pseudouridine in mRNA enhances translation through eIF2α-dependent and independent mechanisms by increasing ribosome density. Nucleic Acids Res. 2017 Jun 2;45(10):6023-6036.
Calculator

Molecular Weight Calculator

Dilution Calculator

Molarity Calculator

molnova catalog
related products

  • AST 7062601

    AST 7062601 is a potent Ucp1 inducer that promotes endogenous Ucp1 expression in primary mouse brown adipocytes.AST 7062601 may be useful in the study of obesity.

  • ZLDI-8

    ZLDI-8 is an inhibitor of Notch activating/cleaving enzyme ADAM-17 and inhibits the cleavage of Notch protein.ZLDI-8;?it inhibited the cleavage of NOTCH protein, consequently decreased the expression of pro-survival/anti-apoptosis and EMT related proteins.?

  • Polyphyllin?VII

    Polyphyllin VII was highly effective against D. intermedius (EC50: 1.2 mg/L).

Sign In Join Free