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CGP-53353
CAS No. 145915-60-2
CGP-53353( DAPH-7 )
Catalog No. M11980 CAS No. 145915-60-2
CGP-53353 (DAPH-7) is a selective inhibitor of PKCβII with IC50 of 0.41 uM, shows weak activity on PKCβI with IC50 of 3.8 uM.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 50MG | 710 | Get Quote |
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| 100MG | 1152 | Get Quote |
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| 200MG | Get Quote | Get Quote |
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| 500MG | Get Quote | Get Quote |
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| 1G | Get Quote | Get Quote |
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Biological Information
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Product NameCGP-53353
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NoteResearch use only, not for human use.
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Brief DescriptionCGP-53353 (DAPH-7) is a selective inhibitor of PKCβII with IC50 of 0.41 uM, shows weak activity on PKCβI with IC50 of 3.8 uM.
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DescriptionCGP-53353 (DAPH-7) is a selective inhibitor of PKCβII with IC50 of 0.41 uM, shows weak activity on PKCβI with IC50 of 3.8 uM; also inhibits prionogenic Sup35 fibrillization (IC50= 3.4 uM) and inhibits de novo Aβ42 assembly in vitro.
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In VitroCGP-53353 (DAPH-7) (1 μM; 48-96 hours) inhibits glucose-induced cell proliferation in A10 cells.CGP-53353 (1 μM ; 0-48 hours) inhibits the glucose-induced increase and acceleration of DNA synthesis in A10, also blocks the glucose-induced increase of S-phase cell percentage. Cell Proliferation AssayCell Line:A10 (cell proliferation induced by glucose) Concentration:1 μM Incubation Time:48-96 hours Result:Inhibited glucose-induced cell proliferation, although A10 cell proliferation was stimulated by increasing glucose concentrations.
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In Vivo——
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SynonymsDAPH-7
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PathwayAngiogenesis
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TargetPKC
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RecptorPKC
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Research Area——
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Indication——
Chemical Information
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CAS Number145915-60-2
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Formula Weight365.34
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Molecular FormulaC20H13F2N3O2
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : ≥ 50 mg/mL (136.86 mM)
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SMILESO=C1NC(C2=C1C=C(NC3=CC=C(F)C=C3)C(NC4=CC=C(F)C=C4)=C2)=O
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Chemical Name5,6-bis[(4-Fluorophenyl)amino]-1H-isoindole-1,3(2H)-dione
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Kouroedov A, et al. Circulation. 2004 Jul 6;110(1):91-6.
2. Wang H, et al. Proc Natl Acad Sci U S A. 2008 May 20;105(20):7159-64.
3. Chalfant CE, et al. Mol Endocrinol. 1996 Oct;10(10):1273-81.
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