Cart
sales@molnova.com
CCI-006
CAS No. 292053-42-0
CCI-006( —— )
Catalog No. M22449 CAS No. 292053-42-0
CCI-006 is a selective inhibitor and chemosensitizer of MLL-rearranged leukemia cells. It inhibits mitochondrial respiration resulting in insurmountable mitochondrial depolarization and a pro-apoptotic unfolded protein response in a subset of MLL-r leukemia cells.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 129 | In Stock |
|
| 5MG | 222 | In Stock |
|
| 10MG | 349 | In Stock |
|
| 25MG | 583 | In Stock |
|
| 50MG | 833 | In Stock |
|
| 100MG | 1134 | In Stock |
|
| 500MG | 2268 | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
-
Product NameCCI-006
-
NoteResearch use only, not for human use.
-
Brief DescriptionCCI-006 is a selective inhibitor and chemosensitizer of MLL-rearranged leukemia cells. It inhibits mitochondrial respiration resulting in insurmountable mitochondrial depolarization and a pro-apoptotic unfolded protein response in a subset of MLL-r leukemia cells.
-
DescriptionCCI-006 is a selective inhibitor and chemosensitizer of MLL-rearranged leukemia cells. It inhibits mitochondrial respiration resulting in insurmountable mitochondrial depolarization and a pro-apoptotic unfolded protein response in a subset of MLL-r leukemia cells.
-
In Vitro——
-
In Vivo——
-
Synonyms——
-
PathwayOthers
-
TargetOther Targets
-
RecptorMitochondria
-
Research Area——
-
Indication——
Chemical Information
-
CAS Number292053-42-0
-
Formula Weight332.33
-
Molecular FormulaC15H12N2O5S
-
Purity>98% (HPLC)
-
SolubilityDMSO:83.33 mg/mL (250.74 mM)
-
SMILESCOC(=O)C(\C#N)=C\c1ccc(o1)-c1ccc(cc1)S(N)(=O)=O
-
Chemical Name——
Shipping & Storage Information
-
Storage(-20℃)
-
ShippingWith Ice Pack
-
Stability≥ 2 years
Reference
1. Somers K, et al. A novel small molecule that kills a subset of MLL-rearranged leukemia cells by inducing mitochondrial dysfunction. Oncogene. 2019 Jan 22.
molnova catalog
related products
-
2-Iodobenzoic acid
2-Iodobenzoic acid is the impact-sensitive intermediate in the synthesis of the Dess-Martin periodinane.
-
[Arg8]-Vasotocin TFA...
[Arg8]-Vasotocin (TFA) is a nonmammalian vertebrate neurohypophyseal peptide.
-
IKKγ NBD Inhibitory ...
A cell-permeable synthetic peptide NEMO-binding domain peptide (NBD peptide) corresponding to the NEMO amino-terminal alpha-helical region is shown to block TNF-alpha-induced NF-kB activation. The interaction of IKγNEMO with the IKK complex is vital for the activation of the IKK complex and the subsequent activation of NF-kB.
