CAY10595( —— )

Catalog No. M26090 CAS No. 916047-16-0

CAY10595 is an antagonist of the CRTh2 (DP2) receptor with a Ki of 10 nM.

Purity : >98% (HPLC)

COA

Datasheet

HNMR

HPLC

MSDS

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Biological Information

Product Name

CAY10595
Note

Research use only, not for human use.
Brief Description

CAY10595 is an antagonist of the CRTh2 (DP2) receptor with a Ki of 10 nM.
Description

CAY10595 is an antagonist of the CRTh2 (DP2) receptor with a Ki of 10 nM.(In Vivo):CAY10595 slightly delays the development of CIA and reduces IgG2a anti-CII levels without modification of the levels of IgG anti-CII.
In Vitro

CAY10595 (compound 71) is a potent CRTH2/DP2 receptor antagonist that binds to the human receptor with a Ki of 10 nM.
In Vivo

Administration of the DP2 antagonist CAY10595 slightly delays the development of CIA. Treatment with CAY10595 reduces IgG2a anti-CII levels without modification of IgG anti-CII levels.
Synonyms

——
Pathway

Cell Cycle/DNA Damage
Target

GPR
Recptor

CK2| MELK| Mps1| NEK6
Research Area

——
Indication

——

Chemical Information

CAS Number

916047-16-0
Formula Weight

451.23
Molecular Formula

C20H13Cl2FN2O5
Purity

>98% (HPLC)
Solubility

——
SMILES

O=C(O)CN1C(=O)C2(C(=O)N(C(=O)C2)CC3=CC(Cl)=CC=C3F)C4=CC(Cl)=CC=C41
Chemical Name

——

Shipping & Storage Information

Storage

(-20℃)
Shipping

With Ice Pack
Stability

≥ 2 years

Reference

1.Colombo R, et al. Targeting the mitotic checkpoint for cancer therapy with NMS-P715, an inhibitor of MPS1 kinase. Cancer Res. 2010 Dec 15;70(24):10255-64.

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