CAT639( CAT 639 | CAT-639 )

Catalog No. M17031 CAS No. ——

COA

Datasheet

HNMR

HPLC

MSDS

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Product Name

CAT639
Note

Research use only, not for human use.
Brief Description

CAT639 is an improved analog of ATV399 that exhibits improved β-cell viability and insulin secretion in the rat insulin-producing INS1E cells and primary rat dispersed islet cells.
Description

CAT639 is an improved analog of ATV399 that exhibits improved β-cell viability and insulin secretion in the rat insulin-producing INS1E cells and primary rat dispersed islet cells, inhibits dimerization of iNOS; reduces the production of nitric oxide (NO) by allosterically inhibiting dimerization of the inducible nitric oxide synthase (iNOS) without affecting its mRNA levels; robustly inhibitscaspase-9 activity at sub-micromolar levels (IC50=0.48 uM), also exhibits potent inhibition of CYP3A4; protects primary rat islet survival and function impaired by cytokines.
In Vitro

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In Vivo

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Synonyms

CAT 639 | CAT-639
Pathway

Immunology/Inflammation
Target

NOS
Recptor

NOS
Research Area

——
Indication

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CAS Number

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Formula Weight

479.551
Molecular Formula

C25H25N3O5S
Purity

>98% (HPLC)
Solubility

——
SMILES

O=C(C1=CC=C(OCO2)C2=C1)NC3=CC=C(S(=O)(N4C(C5=CC=C(C)N=C5)CCCC4)=O)C=C3
Chemical Name

N-(4-((2-(6-methylpyridin-3-yl)piperidin-1-yl)sulfonyl)phenyl)benzo[d][1,3]dioxole-5-carboxamide

1. Zhong L, et al. Br J Pharmacol. 2018 Jun 11. doi: 10.1111/bph.14388.

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