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Butibufen
CAS No. 55837-18-8
Butibufen( —— )
Catalog No. M34198 CAS No. 55837-18-8
Butibufen (FF-106) is an orally active non-steroidal anti-inflammatory compound, a potential cyclooxygenase inhibitor with analgesic and antipyretic activity, and inhibits urea synthesis.Butibufen has been used in the study of rheumatic diseases.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 53 | Get Quote |
|
| 5MG | 72 | Get Quote |
|
| 10MG | 104 | Get Quote |
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| 25MG | 165 | Get Quote |
|
| 50MG | 246 | Get Quote |
|
| 100MG | 356 | Get Quote |
|
| 500MG | 848 | Get Quote |
|
| 1G | Get Quote | Get Quote |
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Biological Information
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Product NameButibufen
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NoteResearch use only, not for human use.
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Brief DescriptionButibufen (FF-106) is an orally active non-steroidal anti-inflammatory compound, a potential cyclooxygenase inhibitor with analgesic and antipyretic activity, and inhibits urea synthesis.Butibufen has been used in the study of rheumatic diseases.
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DescriptionButibufen is an orally active non-steroidal compound. Butibufen shows analgesic and antipyretic properties. Butibufen can be used for the research of inflammation.
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In VitroButibufen (0.1 μM-0.1 M; 60 min) affects cell viability and cell attachment with a high dose.Butibufen (1 μM; 48 h) causes a 100% cell death after 48 h exposure.Butibufen (2 μM-1 mM; 6 h) affects synthesis of albumin in hepatocytes.Butibufen (0.2-0.4 mM; 6 h) impaires gluconeogenesis from lactate and significantly inhibited ureogenesis.Cell Viability Assay Cell Line:Hepatocytes from Sprague-Dawley male rats Concentration:0.1 μM-0.1 M Incubation Time:60 min Result:Showed no cell viability effects under the dose of 200 μM, but dose- and time-dependently affected cell viability with higher concentrations.
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In VivoButibufen (50 and 250 mg/kg; p.o. 8 and 3 h before sacrifice) affects acid phosphatase activity.Animal Model:Sprague-Dawley rats Dosage:50 and 250 mg/kg Administration:Oral gavage; 50 and 250 mg/kg; 8 and 3 h before sacrifice Result:Reduced acid phosphatase activity but showed no effect on the stabilization of lysosomal membrane.
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Synonyms——
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PathwayImmunology/Inflammation
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TargetLipoxygenase
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RecptorLipoxygenase
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Research Area——
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Indication——
Chemical Information
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CAS Number55837-18-8
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Formula Weight220.31
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Molecular FormulaC14H20O2
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Purity>98% (HPLC)
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Solubility——
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SMILESO=C(O)C(C1=CC=C(C=C1)CC(C)C)CC
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Aparicio L. Some aspects of the pharmacology of butibufen, a non-steroidal anti-inflammatory agent. Arch Int Pharmacodyn Ther. 1977 May;227(1):130-41. ?
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