Bithionol

Research use only, not for human use.

Bithionol, formerly marketed as an active ingredient in various topical drug products, was shown to be a potent photosensitizer with the potential to cause serious skin disorders.

Bithionol, formerly marketed as an active ingredient in various topical drug products, was shown to be a potent photosensitizer with the potential to cause serious skin disorders. Approvals of the NDA’s for bithionol drug products were withdrawn on 1967.(In Vitro):Bithionol (0.1-10 mg/mL, 72 h) shows toxicity to Neoparamoeba spp parasites in sea water.Bithionol (0-100 μM) inhibits adenylyl cyclase (AC) activity with an IC50 value of 4 μM.Bithionol (50 and 100 μM, 0-10 min) decreases in cAMP formation with essentially complete inhibition of sAC-dependent cAMP accumulation in sAC-overexpressing 4-4 cells.(In Vivo):Bithionol (100 mg/kg/day, oral administration for 12 days) is moderately active against immature H. nana in mice.

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Animal Model:Immature H. nana infected mice Dosage:100 mg/kg/day Administration:Oral administration, for 12 days post-infection. Result:Eliminated 48% of mature H. nana.LD50: 760 mg/kg.

CP 3438 | NSC 9872 | NSC 47129

GPCR/G Protein

cAMP

sAC

Cancer

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97-18-7

356.04

C12H6Cl4O2S

>98% (HPLC)

DMSO: 7 mg/mL;Water: 68 mg/mL

ClC1=CC(Cl)=C(O)C(SC2=CC(Cl)=CC(Cl)=C2O)=C1

6,6'-thiobis(2,4-dichlorophenol)

(-20℃)

With Ice Pack

≥ 2 years