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Balapiravir

CAS No. 690270-29-2

Balapiravir( R-1626 | R 1626 | Ro 4588161 | R1626 | Ro4588161 | Ro-4588161 )

Catalog No. M15642 CAS No. 690270-29-2

The prodrug of R1479, a potent, specific and oral HCV NS5B polymerase inhibitor.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    Balapiravir
  • Note
    Research use only, not for human use.
  • Brief Description
    The prodrug of R1479, a potent, specific and oral HCV NS5B polymerase inhibitor.
  • Description
    The prodrug of R1479, a potent, specific and oral HCV NS5B polymerase inhibitor; demonstrates strong capacity to inhibit HCV replication in vitro and in vivo, without the rapid development of viral resistance.HCV Infection Phase 2 Discontinued.
  • In Vitro
    ——
  • In Vivo
    After oral dosing of the CD-1 mice with 28.1 mg/kg of balapiravir (Ro 4588161; R1626), R1479 reaches a Cmax and a minimum concentration in plasma (Cmin) of 24.38 μM and 6.34 μM, respectively, at 2 h and 24 h postdosing.
  • Synonyms
    R-1626 | R 1626 | Ro 4588161 | R1626 | Ro4588161 | Ro-4588161
  • Pathway
    Microbiology/Virology
  • Target
    HCV
  • Recptor
    HCV
  • Research Area
    Infection
  • Indication
    HCV Infection

Chemical Information

  • CAS Number
    690270-29-2
  • Formula Weight
    494.4983
  • Molecular Formula
    C21H30N6O8
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO: ≥ 100 mg/mL
  • SMILES
    CC(C(O[C@H]([C@@H]([C@]1(COC(C(C)C)=O)N=[N+]=[N-])OC(C(C)C)=O)[C@@H](O1)N(C=CC(N)=N2)C2=O)=O)C
  • Chemical Name
    Cytidine, 4'-C-azido-, 2',3',5'-tris(2-methylpropanoate)

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Roberts SK, et al. Hepatology. 2008 Aug;48(2):398-406. 2. McCown MF, et al. Antimicrob Agents Chemother. 2008 May;52(5):1604-12. 3. Chen YL, et al. J Virol. 2014 Feb;88(3):1740-7. 4. Toniutto P, et al. IDrugs. 2008 Oct;11(10):738-49.
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