BT18( —— )

Catalog No. M24975 CAS No. 924811-53-0

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

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Product Name

BT18
Note

Research use only, not for human use.
Brief Description

BT18 is a mimic with function similar to glial cell line-derived neurotrophic factor (GDNF).
Description

BT18 is a mimic with function similar to glial cell line-derived neurotrophic factor (GDNF). BT18 has an effect on RET receptor tyrosine kinase RetA and GDNF family receptor GFRα1 function.
In Vitro

BT18 (50 μM; 1-90 minutes) activates AKT and ERK1/2 in time-dependently in MG87RET cell lines.BT18 (1-50 μM; 90 minutes) activates AKT in a dose-dependent manner in MG87RET cell lines.BT18 (5-50 μM; 15 mimutes) appears to phosphorylate RET in concentration of 50 μM both in GFP-transfected and in GFRD1-transfected cells. Western Blot Analysis Cell Line:MG87RET cell lines Concentration:50 μM Incubation Time:1, 5, 15, 45, 90 minutes Result:Activated AKT and ERK1/2 in time-dependently.
In Vivo

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Synonyms

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Pathway

Others
Target

Other Targets
Recptor

Others
Research Area

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Indication

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CAS Number

924811-53-0
Formula Weight

637.64
Molecular Formula

C30H31F4N3O6S
Purity

>98% (HPLC)
Solubility

DMSO: 98 mg/mL (153.69 mM; Need ultrasonic)
SMILES

COc(ccc(S(N(CC1)Cc(cc2OC)c1cc2OC)(=O)=O)c1)c1N(CC1)CCN1C(c(cc1)c(C(F)(F)F)cc1F)=O
Chemical Name

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