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BRD-73954

CAS No. 1440209-96-0

BRD-73954( BRD73954 )

Catalog No. M11867 CAS No. 1440209-96-0

The first HDAC6/8 dual inhibitor with IC50s of 36/120 nM.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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2MG 45 In Stock
5MG 81 In Stock
10MG 136 In Stock
25MG 273 In Stock
50MG 412 In Stock
100MG 606 In Stock
500MG 1287 In Stock
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Biological Information

  • Product Name
    BRD-73954
  • Note
    Research use only, not for human use.
  • Brief Description
    The first HDAC6/8 dual inhibitor with IC50s of 36/120 nM.
  • Description
    The first HDAC6/8 dual inhibitor with IC50s of 36/120 nM; show no significant inhibition for other HDAC isoforms (IC50>9 uM); robustly increase in α-tubulin acetylation, has no change in the acetylation state of H3 in Hela cells.
  • In Vitro
    BRD73954 (10 μM; 48 h; HeLa cells) inhibits HDAC6 activity via upregulation of Ac-Tubulin. Western Blot Analysis Cell Line:HeLa cells Concentration:10 μM Incubation Time:48 hours Result:Increased inα-tubulin acetylation, no change in the acetylation state of H3 was observed.
  • In Vivo
    ——
  • Synonyms
    BRD73954
  • Pathway
    Cell Cycle/DNA Damage
  • Target
    HDAC
  • Recptor
    HDAC2|HDAC4|HDAC6|HDAC8
  • Research Area
    Cancer
  • Indication
    ——

Chemical Information

  • CAS Number
    1440209-96-0
  • Formula Weight
    284.3098
  • Molecular Formula
    C16H16N2O3
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO: ≥ 35 mg/mL
  • SMILES
    C1=CC=C(C=C1)CCNC(=O)C2=CC(=CC=C2)C(=O)NO
  • Chemical Name
    1,3-Benzenedicarboxamide, N1-hydroxy-N3-(2-phenylethyl)-

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Olson DE, et al. J Med Chem. 2013 Jun 13;56(11):4816-20.
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