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BMS-684

CAS No. 313552-29-3

BMS-684( —— )

Catalog No. M37108 CAS No. 313552-29-3

BMS-684 is a selective and potent DGKα inhibitor (IC50: 15 nM) with potential antitumor activity.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    BMS-684
  • Note
    Research use only, not for human use.
  • Brief Description
    BMS-684 is a selective and potent DGKα inhibitor (IC50: 15 nM) with potential antitumor activity.
  • Description
    BMS-684 is a selective DGKα inhibitor with an IC50 of 15 nM. BMS-684 inhibits DGKα kinase activity with >100-fold selectivity over the related DGK type I family members DGKβ and DGKγ. BMS-684 does not inhibit any of the other seven DGK isozymes.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    ——
  • Pathway
    Others
  • Target
    Other Targets
  • Recptor
    Others
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    313552-29-3
  • Formula Weight
    454.52
  • Molecular Formula
    C27H26N4O3
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    O=C1C([N+]([O-])=O)=C(N2CCN(C(C3=CC=CC=C3)C4=CC=CC=C4)CC2)C5=C(N1C)C=CC=C5
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Michael Wichroski, et al. DGKα/ζ inhibitors combine with PD-1 checkpoint therapy to promote T cell-mediated antitumor immunity. Sci Transl Med. 2023 Oct 25;15(719):eadh1892. ?
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