BMS-684( —— )

Catalog No. M37108 CAS No. 313552-29-3

BMS-684 is a selective and potent DGKα inhibitor (IC50: 15 nM) with potential antitumor activity.

Purity : >98% (HPLC)

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

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5MG	312	In Stock
10MG	502	In Stock
25MG	778	In Stock
50MG	1040	In Stock
100MG	1377	In Stock
500MG	2673	In Stock
1G	Get Quote	In Stock

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Biological Information

Product Name

BMS-684
Note

Research use only, not for human use.
Brief Description

BMS-684 is a selective and potent DGKα inhibitor (IC50: 15 nM) with potential antitumor activity.
Description

BMS-684 is a selective DGKα inhibitor with an IC50 of 15 nM. BMS-684 inhibits DGKα kinase activity with >100-fold selectivity over the related DGK type I family members DGKβ and DGKγ. BMS-684 does not inhibit any of the other seven DGK isozymes.
In Vitro

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In Vivo

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Synonyms

——
Pathway

Others
Target

Other Targets
Recptor

Others
Research Area

——
Indication

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Chemical Information

CAS Number

313552-29-3
Formula Weight

454.52
Molecular Formula

C27H26N4O3
Purity

>98% (HPLC)
Solubility

——
SMILES

O=C1C([N+]([O-])=O)=C(N2CCN(C(C3=CC=CC=C3)C4=CC=CC=C4)CC2)C5=C(N1C)C=CC=C5
Chemical Name

——

Shipping & Storage Information

Storage

(-20℃)
Shipping

With Ice Pack
Stability

≥ 2 years

Reference

1. Michael Wichroski, et al. DGKα/ζ inhibitors combine with PD-1 checkpoint therapy to promote T cell-mediated antitumor immunity. Sci Transl Med. 2023 Oct 25;15(719):eadh1892. ?

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