BMS-681( BMS 681 | BMS681 )

Catalog No. M16155 CAS No. 847998-92-9

COA

Datasheet

HNMR

HPLC

MSDS

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Product Name

BMS-681
Note

Research use only, not for human use.
Brief Description

A potent and orally bioavailable dual antagonist of CCR2 and CCR5 with binding IC50 of 0.7 nM and 2.4 nM, respectively.
Description

A potent and orally bioavailable dual antagonist of CCR2 and CCR5 with binding IC50 of 0.7 nM and 2.4 nM, respectively; exhibits high selectivity against other chemokine receptors and GPCRs; shows CCR2 functional assays of monocyte chemotaxis (IC50=0.24 nM) and CD11b upregulation (whole blood IC50=4.7 nM), CCR5 functional assays of human T-cells (IC50=2.3 nM) and whole blood CCR5-mediated CD11b upregulation (IC50=4.3 nM); suitable for use in both murine and monkey models of inflammation.
In Vitro

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In Vivo

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Synonyms

BMS 681 | BMS681
Pathway

GPCR/G Protein
Target

Chemokine Receptor
Recptor

Chemokine Receptor
Research Area

——
Indication

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CAS Number

847998-92-9
Formula Weight

491.603
Molecular Formula

C26H36F3N5O
Purity

>98% (HPLC)
Solubility

——
SMILES

CCCC1CC(CCC1N2CCC(C2=O)NC3=NC=NC4=C3C=C(C=C4)C(F)(F)F)N(C)C(C)C
Chemical Name

1-((1S,2R,4R)-4-(isopropyl(methyl)amino)-2-propylcyclohexyl)-3-((6-(trifluoromethyl)quinazolin-4-yl)amino)pyrrolidin-2-one

1. Zheng Y, et al. Nature. 2016 Dec 15;540(7633):458-461. 2. Carter PH, et al. ACS Med Chem Lett. 2015 Mar 4;6(4):439-44.

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