Cart
sales@molnova.com
BMS-394136
CAS No. 343246-73-1
BMS-394136( BMS394136 )
Catalog No. M14168 CAS No. 343246-73-1
BMS-394136 is a potent, selective IKur/Kv1.5inhibitor.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 581 | Get Quote |
|
| 10MG | 827 | Get Quote |
|
| 25MG | 1242 | Get Quote |
|
| 50MG | 1674 | Get Quote |
|
| 100MG | 2241 | Get Quote |
|
| 500MG | 4437 | Get Quote |
|
| 1G | Get Quote | Get Quote |
|
Biological Information
-
Product NameBMS-394136
-
NoteResearch use only, not for human use.
-
Brief DescriptionBMS-394136 is a potent, selective IKur/Kv1.5inhibitor.
-
DescriptionBMS-394136 is a potent, selective IKur/Kv1.5inhibitor, increases atrial action potential duration (APD) and prolongs AERP but not VERP in both rabbits and beagles.Heart Arrhythmia Phase 1 Discontinued.
-
In Vitro——
-
In Vivo——
-
SynonymsBMS394136
-
PathwayCell Cycle/DNA Damage
-
TargetPotassium Channel
-
RecptorPotassium Channel
-
Research AreaCardiovascular Disease
-
IndicationHeart Arrhythmia
Chemical Information
-
CAS Number343246-73-1
-
Formula Weight471.357
-
Molecular FormulaC24H21Cl2FN4O
-
Purity>98% (HPLC)
-
Solubility——
-
SMILESCC1=C([C@H](n2c(ccn2)N1)c3ccc(c(c3)Cl)Cl)C(=O)N4CCC[C@H]4c5ccc(cc5)F
-
Chemical NamePyrrolidine, 1-[[(7R)-7-(3,4-dichlorophenyl)-4,7-dihydro-5-methylpyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]-2-(4-fluorophenyl)-, (2S)- (9CI)
Shipping & Storage Information
-
Storage(-20℃)
-
ShippingWith Ice Pack
-
Stability≥ 2 years
Reference
1. Dezhi Xing, et al. Abstract 2515: A Selective IKur Blocker, BMS-394136 Selectively Prolongs Atrial APD and Refractoriness in Beagles and Rabbits. Circulation. 2009;120:S654.
molnova catalog
related products
-
Margatoxin
Potent KV1.3 channel blocker (IC50 = 36 pM). Displays no effect at calcium-activated channels. Reduces VEGF-induced transmembrane calcium influxes and nitric oxide production in human endothelial cells.
-
TRAM 39
TRAM 39 is a selective blocker of intermediate-conductance Ca2+-activated K+channels.
-
QO-40
QO-40 is a KCNQ2/3 potassium channels activator.QO-40 potently augmented KCNQ2/3 channels expressed in Chinese hamster ovary cells and shifted the half-maximal activation voltage (V(1/2)) in the hyperpolarizing direction.?The V(1/2) was negatively shifted in a concentration-dependent manner.?
