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BIO-013077-01

CAS No. 746667-48-1

BIO-013077-01( —— )

Catalog No. M21624 CAS No. 746667-48-1

BIO-013077-01 is a potent TGFbeta family type I receptors antagonist.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    BIO-013077-01
  • Note
    Research use only, not for human use.
  • Brief Description
    BIO-013077-01 is a potent TGFbeta family type I receptors antagonist.
  • Description
    BIO-013077-01 is a potent TGFbeta family type I receptors antagonist.
  • In Vitro
    A wide range of cellular functions such as cell proliferation, differentiation, adhesion, migration, and apoptosis are regulated by TGF-β superfamily members. The TGF-βs include the three major TGF-β isoforms, TGF-β1, TGF-β2, and TGF-β3 which are expressed in mammals. TGF-β transduces signals through a complex of two related but structurally and functionally distinct serine/threonine kinase receptors, termed type 1 and type II. Deregulation of TGF-β signaling has been also implicated in various human diseases including cancer, pancreatic diseases, and hematological malignancies.
  • In Vivo
    ——
  • Synonyms
    ——
  • Pathway
    Others
  • Target
    Other Targets
  • Recptor
    TGFβ
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    746667-48-1
  • Formula Weight
    287.32
  • Molecular Formula
    C17H13N5
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 100 mg/mL (348.04 mM)
  • SMILES
    Cc1cccc(n1)-c1n[nH]cc1-c1ccc2nccnc2c1
  • Chemical Name
    6-[3-(6-Methylpyridin-2-yl)-1H-pyrazol-4-yl]quinoxaline

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Koike R Uchiyama T Arimoto-Kobayashi S Okamoto K Negishi T. Increase of somatic cell mutations in oxidative damage-sensitive drosophila. Genes Environ. 2018 Jan 10;40:3.
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