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Home - Products - Cell Cycle/DNA Damage - GPR - BI-671800

BI-671800

CAS No. 1093108-50-9

BI-671800( AP-761 | Cmpd A )

Catalog No. M23296 CAS No. 1093108-50-9

BI-671800 is a highly specific and potent antagonist of chemoattractant receptor-homologous molecule on Th2 cells (DP2/CRTH2).

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    BI-671800
  • Note
    Research use only, not for human use.
  • Brief Description
    BI-671800 is a highly specific and potent antagonist of chemoattractant receptor-homologous molecule on Th2 cells (DP2/CRTH2).
  • Description
    BI-671800 is a highly specific and potent antagonist of chemoattractant receptor-homologous molecule on Th2 cells (DP2/CRTH2). With IC50 values of 4.5 nM and 3.7 nM for PGD2 binding to CRTH2 in hCRTH2 and mCRTH2 transfected cells, respectively. BI-671800 has potential for the treatment of poorly controlled asthma.
  • In Vitro
    BI-671800 (compound A) exhibits low nM potency as an antagonist of human or mouse CRTH2 in transfected cells.
  • In Vivo
    BI-671800 (compound A, 0.1-10 mg/kg, i.g.) shows significant inhibition of AHR in mice. BI-671800 (compound A), effectively blocks edema formation and greatly reduces the inflammatory infiltrate and skin pathology observed in drug vehicle-treated animals. Animal Model:6-8-week-old age- and sex-matched BALB/c mice (mice were sensitized for 14 days, challenged intranasally).Dosage:10-0.1 mg/kg Administration:Oral gavage for 4 weeks Result:Shows significant inhibition of AHR in mice.
  • Synonyms
    AP-761 | Cmpd A
  • Pathway
    Cell Cycle/DNA Damage
  • Target
    GPR
  • Recptor
    CRTh2 (DP2) receptor|hCRTH2|mCRTH2
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    1093108-50-9
  • Formula Weight
    501.5
  • Molecular Formula
    C25H26F3N5O3
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO:130 mg/mL (259.22 mM; Need ultrasonic)
  • SMILES
    CN(C)c1nc(Cc(cc2)ccc2NC(c2ccc(C(F)(F)F)cc2)=O)nc(N(C)C)c1CC(O)=O
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Boehme SA, et al. A small molecule CRTH2 antagonist inhibits FITC-induced allergic cutaneous inflammation. Int Immunol. 2009 Jan;21(1):81-93.
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