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BHPI
CAS No. 56632-39-4
BHPI( BHPI | )
Catalog No. M15059 CAS No. 56632-39-4
BHPI is a potent, noncompetitive small molecule ERα inhibitor.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 50MG | 680 | Get Quote |
|
| 100MG | 1116 | Get Quote |
|
| 200MG | Get Quote | Get Quote |
|
| 500MG | Get Quote | Get Quote |
|
| 1G | Get Quote | Get Quote |
|
Biological Information
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Product NameBHPI
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NoteResearch use only, not for human use.
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Brief DescriptionBHPI is a potent, noncompetitive small molecule ERα inhibitor.
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DescriptionBHPI is a potent, noncompetitive small molecule ERα inhibitor (biomodulator) that selectively blocks proliferation of drug-resistant ERα-positive breast and ovarian cancer cells; distorts this normal action of E2–ERα and induces a massive and sustained ERα-dependent activation of the unfolded protein response (UPR), persistent inhibition of protein synthesis, converting UPR activation from cytoprotective to cytotoxic; completely blocked proliferation of ERα+ cancer cells at 100-1000 nM, induces tumor regression in mouse xenograft of MCF-7 cells.
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In Vitro——
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In Vivo——
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SynonymsBHPI |
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PathwayEndocrinology/Hormones
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TargetEstrogen Receptor/ERR
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RecptorEstrogen Receptor/ERR
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Research AreaCancer
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Indication——
Chemical Information
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CAS Number56632-39-4
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Formula Weight331.3646
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Molecular FormulaC21H17NO3
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Purity>98% (HPLC)
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SolubilityDMSO: ≥150 mg/mL
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SMILESO=C1NC2=C(C=CC=C2C)C1(C3=CC=C(O)C=C3)C4=CC=C(O)C=C4
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Chemical Name2H-Indol-2-one, 1,3-dihydro-3,3-bis(4-hydroxyphenyl)-7-methyl-
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Andruska ND, et al. Proc Natl Acad Sci U S A. 2015 Apr 14;112(15):4737-42.
2. Zheng X, et al. Oncotarget. 2016 Jul 24;9(19):14741-14753.
3. Mao C, et al. Sci Rep. 2016 Oct 7;6:34753.
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