Cart
sales@molnova.com
BC1618
CAS No. 2222094-18-8
BC1618( 2-Propanol, 1-[bis(phenylmethyl)amino]-3-[4-(trifluoromethyl)phenoxy]- )
Catalog No. M24005 CAS No. 2222094-18-8
BC1618 is an orally active Fbxo48 inhibitory compound, stimulates Ampk-dependent signaling.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 68 | In Stock |
|
| 10MG | 110 | In Stock |
|
| 25MG | 222 | In Stock |
|
| 50MG | 380 | In Stock |
|
| 100MG | 565 | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
-
Product NameBC1618
-
NoteResearch use only, not for human use.
-
Brief DescriptionBC1618 is an orally active Fbxo48 inhibitory compound, stimulates Ampk-dependent signaling.
-
DescriptionBC1618 is an orally active Fbxo48 inhibitory compound, stimulates Ampk-dependent signaling. It promotes mitochondrial fission, facilitates autophagy and improves hepatic insulin sensitivity.
-
In VitroWestern Blot Analysis Cell Line:BEAS-2B cells.Concentration:0-2 μM.Incubation Time:16 h.Result:Induced pAmpkα and pACC protein levels dose-dependently.
-
In VivoAnimal Model:C57BL/6 mice.Dosage:2 or 10 mg/kg (challenged with LPS (3 mg/kg) for an additional 18 h).Administration:IP, once.Result:Reduced lung inflammation in endotoxin treated mice.Animal Model:C57BL/6 mice.Dosage:15 and 30 mg/kg/d.Administration:Drinking water for 3 months.Result:Exhibited no obvious toxicity.
-
Synonyms2-Propanol, 1-[bis(phenylmethyl)amino]-3-[4-(trifluoromethyl)phenoxy]-
-
PathwayMembrane Transporter/Ion Channel
-
TargetAMPK
-
RecptorAMPK|E1/E2/E3 Enzyme|Fbxo48|Mitophagy
-
Research Area——
-
Indication——
Chemical Information
-
CAS Number2222094-18-8
-
Formula Weight415.45
-
Molecular FormulaC24H24F3NO2
-
Purity>98% (HPLC)
-
SolubilityDMSO:100 mg/mL?(240.70 mM;?Need ultrasonic)
-
SMILESOC(COC1=CC=C(C(F)(F)F)C=C1)CN(CC2=CC=CC=C2)CC3=CC=CC=C3
-
Chemical Name——
Shipping & Storage Information
-
Storage(-20℃)
-
ShippingWith Ice Pack
-
Stability≥ 2 years
Reference
1.Yuan Liu, et al. A Fbxo48 inhibitor prevents pAMPKα degradation and ameliorates insulin resistance. Nat Chem Biol. 2021 Mar;17(3):298-306.
molnova catalog
related products
-
Karanjin
Karanjin is a flavonoid?obtained from the seeds of the karanja tree.Karanjin induces GLUT4 translocation in skeletal muscle cells by increasing AMPK activity.
-
Gomisin J
Gomisin J is a natural product and have vasodilatory activity.?Gomisin J suppresses lipid accumulation by regulating the expression of lipogenic and lipolytic enzymes and inflammatory molecules through activation of AMPK, LKB1 and Ca2+/calmodulin-dependent protein kinase II and inhibition of fetuin-A in HepG2 cells.
-
XMD-17-51
XMD-17-51 is a potent and highly selective NUAK1 inhibitor.
