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Azido-PEG4-hydrazide

CAS No. 2170240-96-5

Azido-PEG4-hydrazide( —— )

Catalog No. M33280 CAS No. 2170240-96-5

Azido-PEG4-hydrazide is a PROTAC linker belonging to the PEG class and can be used to synthesize PROTAC molecules.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    Azido-PEG4-hydrazide
  • Note
    Research use only, not for human use.
  • Brief Description
    Azido-PEG4-hydrazide is a PROTAC linker belonging to the PEG class and can be used to synthesize PROTAC molecules.
  • Description
    Azido-PEG4-hydrazide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Azido-PEG4-hydrazide is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. Strain-promoted alkyne-azide cycloaddition (SPAAC) can also occur with molecules containing DBCO or BCN groups.
  • In Vitro
    PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
  • In Vivo
    ——
  • Synonyms
    ——
  • Pathway
    Others
  • Target
    Other Targets
  • Recptor
    PROTACs
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    2170240-96-5
  • Formula Weight
    305.33
  • Molecular Formula
    C11H23N5O5
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 100 mg/mL (327.51 mM; Ultrasonic )
  • SMILES
    [N-]=[N+]=NCCOCCOCCOCCOCCC(=O)NN
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562?
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