Ascamycin( —— )

Catalog No. M33271 CAS No. 91432-48-3

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Product Name

Ascamycin
Note

Research use only, not for human use.
Brief Description

Ascamycin is a 5'-O-sulfonamide ribonucleoside antibiotic produced by Streptomyces spp.
Description

Ascamycin is a 5'-O-sulfonamide ribonucleoside antibiotic produced by Streptomyces sp. JCM9888. Ascamycin has a selective antibacterial activity against Xanthomonas species with MIC values of 0.4 μg/mL, 12.5 μg/mL and 12.5 μg/mL for Xanthomonas citri, Xanthomonas oryzae and Mycobacterium phlei, respectively.
In Vitro

The Ascamycin has C2-chloroadenine as the base on C-1' which lacks the chlorine. Ascamycin has a selective antibacterial activity against Xanthomonas species. When Ascamycin is dealanylated, Dealanylascamycin shows a broad antibacterial activity against various Gram-negative and Gram-positive bacteria. Xanthomonas citri is susceptible to Ascamycin by virtue of the Ascamycin-dealanylating enzyme on the cell surface.
In Vivo

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Synonyms

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Pathway

Microbiology/Virology
Target

Antibiotic
Recptor

Nucleoside Antimetabolite/Analog | Antibacterial | Antibiotic
Research Area

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Indication

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CAS Number

91432-48-3
Formula Weight

451.84
Molecular Formula

C13H18ClN7O7S
Purity

>98% (HPLC)
Solubility

——
SMILES

NC1=C2C(N(C=N2)[C@@H]3O[C@H](COS(NC([C@H](C)N)=O)(=O)=O)[C@@H](O)[C@H]3O)=NC(Cl)=N1
Chemical Name

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1. Isono K, et al. Ascamycin and dealanylascamycin, nucleoside antibiotics from Streptomyces sp. J Antibiot (Tokyo). 1984 Jun;37(6):670-2.?

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