Apostatin-1

Research use only, not for human use.

Apostatin-1 is a novel TRADD inhibitor. Apostatin-1 can bind to a pocket on the N-terminal TRAF2 binding domain of TRADD.

Apostatin-1 is a novel TRADD inhibitor. Apostatin-1 can bind to a pocket on the N-terminal TRAF2 binding domain of TRADD.

Western Blot Analysis Cell Line:SH-SY5Y, HeLa, HT-29, and Jurkat cells Concentration:10 μM Incubation Time:6 h Result:Effectively induced autophagy by LC3 II induction and p62 reduction.

Animal Model:Wild-type mice (n = 10, male, 8 weeks of age, systemic inflammation mouse model)Dosage:20 mg/kgAdministration:IP, onceResult:Reduced expression of the TNF-induced inflammatory target gene products, NOS and COXII27, and of inflammatory cytokines in cells stimulated with pathogen-associated molecular patterns, including interferon γ (IFNγ), lipopolysaccharide (LPS), Pam3CSK4 (a synthetic bacterial lipopeptide), and muramyl dipeptide (MDP). Showed increased survival following intravenous delivery of TNF, a mouse model of systemic inflammation.

Apt-1

Others

Other Targets

TRADD

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2559703-06-7

345.5

C19H27N3OS

>98% (HPLC)

DMSO:65mg/ml(188.13mM; need ultrasonic); Ethanol:9mg/ml(26.06mM; need ultrasonic)

O=C(NC1CCCCCC1)C(C2=CC=CC=C2)SC3=NCCN3C

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(-20℃)

With Ice Pack

≥ 2 years