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Alvimopan dihydrate

CAS No. 170098-38-1

Alvimopan dihydrate( Alvimopan Dihydrate | Entereg | Alvimopan hydrate | LY 246736 dihydrate )

Catalog No. M12598 CAS No. 170098-38-1

A selective peripherally acting μ-opioid antagonist with IC50 of 1.7 nM for the treatment of postoperative ileus; prevents gastrointestinal effects of intravenous morphine without affecting analgesia; orally active.

Purity : >98% (HPLC)

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Biological Information

  • Product Name
    Alvimopan dihydrate
  • Note
    Research use only, not for human use.
  • Brief Description
    A selective peripherally acting μ-opioid antagonist with IC50 of 1.7 nM for the treatment of postoperative ileus; prevents gastrointestinal effects of intravenous morphine without affecting analgesia; orally active.
  • Description
    A selective peripherally acting μ-opioid antagonist with IC50 of 1.7 nM for the treatment of postoperative ileus; prevents gastrointestinal effects of intravenous morphine without affecting analgesia; orally active.Other Indication Approved.
  • In Vitro
    Alvimopan inhibits the loperamide-stimulated [35S]GTPγS binding to membranes containing the cloned human μ-opioid receptor, with an IC50 of 1.7 nM.
  • In Vivo
    Alvimopan (0.1-1.0 mg/kg; p.o.) partially antagonizes the slowing of small intestinal transit of 113Sn-labelled microspheres in rats.Alvimopan (3 mg/kg; p.o.) has no effect on the visceromotor behavioural responses (VMR) induced by noxious colorectal distension (CRD) in conscious rats.
  • Synonyms
    Alvimopan Dihydrate | Entereg | Alvimopan hydrate | LY 246736 dihydrate
  • Pathway
    Endocrinology/Hormones
  • Target
    Opioid Receptor
  • Recptor
    Opioid Receptor
  • Research Area
    Other Indications
  • Indication
    Other Disease

Chemical Information

  • CAS Number
    170098-38-1
  • Formula Weight
    460.5631
  • Molecular Formula
    C25H36N2O6
  • Purity
    >98% (HPLC)
  • Solubility
    10 mM in DMSO
  • SMILES
    O=C(O)CNC([C@@H](CC1=CC=CC=C1)CN2C[C@H](C)[C@](C)(C3=CC=CC(O)=C3)CC2)=O.[H]O[H].[H]O[H]
  • Chemical Name
    Glycine, N-[(2S)-2-[[(3R,4R)-4-(3-hydroxyphenyl)-3,4-dimethyl-1-piperidinyl]methyl]-1-oxo-3-phenylpropyl]-, hydrate (1:2)

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Fukuda H, et al. Brain Res. 2006 Aug 2;1102(1):63-70. 2. Taguchi A, et al. N Engl J Med. 2001 Sep 27;345(13):935-40. 3. Schmidt WK. Am J Surg. 2001 Nov;182(5A Suppl):27S-38S.
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