Albendazole

Research use only, not for human use.

Albendazole is a member of the benzimidazole compounds used as a drug indicated for the treatment of a variety of worm infestations.

Albendazole is a member of the benzimidazole compounds used as a drug indicated for the treatment of a variety of worm infestations.(In Vitro):Albendazole (100, 500, 1000 nM; 1, 3, or 5 days) inhibits cell proliferation in a dose-dependent manner.Albendazole (100, 250, 500, 1000 nM; 3 days) arrests SKHEP-1 cells at both G0–G1 (250, 500 nM) and G2-M (1000 nM) phases of the cycle.Albendazole (5 μM; 24, 36 h) mainly induces early apoptosis in HCT-15 cells and late apoptosis in HCT-1 16, HT29, SW480 cells accompanied with cleavage of PARP and caspase-3 in a time-dependent manner.Albendazole (5 μM; 24, 36 h) induces autophagy via increasing autophagy-related protein (such as LC3, Atg7, p-beclin-1, and beclin-1) expression level in HCT-15, HCT-1 16, HT29, and SW480 cells.Albendazole (500 nM, 24 h) inhibits hypoxia-induced HIF-1α expression and VEGF expression in A549 cells.(In Vivo):Albendazole (10 mg/kg; i.g.; once a day for 30 days) reduces Echinococcus granulosus cyst weights in mice.Albendazole (300 mg/kg; p.o.; per day in two divided dose for 20 days) profoundly suppresses tumor growth in vivo.

Albendazole (100, 500, 1000 nM; 1, 3, or 5 days) inhibits cell proliferation in a dose-dependent manner.Albendazole (100, 250, 500, 1000 nM; 3 days) arrests SKHEP-1 cells at both G0–G1 (250, 500 nM) and G2-M (1000 nM) phases of the cycle.Albendazole (5 μM; 24, 36 h) mainly induces early apoptosis in HCT-15 cells and late apoptosis in HCT-1 16, HT29, SW480 cells accompanied with cleavage of PARP and caspase-3 in a time-dependent manner. Albendazole (5 μM; 24, 36 h) induces autophagy via increasing autophagy-related protein (such as LC3, Atg7, p-beclin-1, and beclin-1) expression level in HCT-15, HCT-1 16, HT29, and SW480 cells.?Albendazole (500 nM, 24 h) inhibits hypoxia-induced HIF-1α expression and VEGF expression in A549 cells.Cell Proliferation Assay Cell Line:SKHEP-1 cells Concentration:100, 500, 1000 nM Incubation Time:1, 3, or 5 days Result:Inhibited cell proliferation in a dose-dependent manner.Cell Cycle Analysis Cell Line:SKHEP-1 HCC cells Concentration:100, 250, 500, 1000 nM Incubation Time:3 days Result:Showed dose-dependent effect on the cell cycle kinetics.Apoptosis Analysis Cell Line:HCT-15, HCT-1 16, HT29, SW480 cells Concentration:5 μM Incubation Time:24, 36 h Result:Promoted apoptosis in colon cancer cells.Cell Autophagy Assay Cell Line:HCT-15, HCT-1 16, HT29, SW480 cells Concentration:5 μM Incubation Time:24, 36 h Result:Induced autophagy in colon cancer cells.Western Blot Analysis Cell Line:HCT-15, HCT-1 16, HT29, SW480 cells Concentration:5 μM Incubation Time:12, 24, 36 h Result:Induced apoptosis-related protein (PARP, caspase-3) and autophagy-related protein (such as LC3, Atg7, p-beclin-1, and beclin-1) expression level in a time-dependent manner.Increased phosphorylation of different MAPKs (AMPK, ERK, JNK, p38) and ULK1 protein in a time dependent manner, and up-regulated the activation of different MAPKs.Caused the activation of both MAPK and AMPK pathways.Western Blot Analysis Cell Line:A549 cellsConcentration:500 nM Incubation Time:24 h Result:Inhibited hypoxia-induced HIF-1α expression and VEGF expression in A549 cells.

Albendazole (10 mg/kg; i.g.; once a day for 30 days) reduces Echinococcus granulosus cyst weights in mice.?Albendazole (300 mg/kg; p.o.; per day in two divided dose for 20 days) profoundly suppresses tumor growth in vivo. Animal Model:Female BALB/c mice (10-week-age; Echinococcus granulosus infection model).Dosage:10 mg/kgAdministration:Oral gavage; once a day for 30 days.Result:Reduced Echinococcus granulosus cyst weights.Animal Model:Male BALB/c Nu/Nu mice (6 to 10-week-old; inoculated subcutaneously with SKHEP-1).Dosage:50, 150, 300 mg/kg Administration:Oral administration; per day in two divided dose for 20 days.Result:Profoundly suppressed tumor growth in vivo.

NSC 220008 | SKF 62979

Cytoskeleton/Cell Adhesion Molecules

Microtubule/Tubulin

microtubule

Infection

——

54965-21-8

265.33

C12H15N3O2S

>98% (HPLC)

DMSO: 17mg/ml (64.07 mM); Water: <1mg/ml; Ethanol: <1mg/ml

CCCSC1=CC2=C(C=C1)N=C(N2)NC(=O)OC

methyl N-(6-propylsulfanyl-1H-benzimidazol-2-yl)carbamate

(-20℃)

With Ice Pack

≥ 2 years