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Adomeglivant

CAS No. 1488363-78-5

Adomeglivant( LY-2409021 )

Catalog No. M12058 CAS No. 1488363-78-5

A potent, selective, orally active, small-molecule antagonist of human glucagon receptor with Ki of 6.66 nM.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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2MG 53 Get Quote
5MG 87 Get Quote
10MG 132 Get Quote
25MG 213 Get Quote
50MG 390 Get Quote
100MG 575 Get Quote
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Biological Information

  • Product Name
    Adomeglivant
  • Note
    Research use only, not for human use.
  • Brief Description
    A potent, selective, orally active, small-molecule antagonist of human glucagon receptor with Ki of 6.66 nM.
  • Description
    A potent, selective, orally active, small-molecule antagonist of human glucagon receptor with Ki of 6.66 nM; displays >200-fold selectivity over related receptors; exhibits robust glucose-lowering in response to daily oral administration in an ob/ob mouse model of type 2 diabetes mellitus.Diabetes Phase 2 Discontinued.
  • In Vitro
    ——
  • In Vivo
    Animal Model:Avpires-Cre+ miceDosage:5 mg/kg Administration:Intraperitoneal injection, 30 minutes prior to CNOResult:Completely abolished the hyperglycaemic action of CNO.
  • Synonyms
    LY-2409021
  • Pathway
    GPCR/G Protein
  • Target
    Glucagon Receptor
  • Recptor
    Glucagon Receptor
  • Research Area
    Metabolic Disease
  • Indication
    Diabetes

Chemical Information

  • CAS Number
    1488363-78-5
  • Formula Weight
    555.6277
  • Molecular Formula
    C32H36F3NO4
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO: ≥ 5.3 mg/mL
  • SMILES
    O=C(O)CCNC(C1=CC=C([C@@H](OC2=CC(C)=C(C3=CC=C(C(C)(C)C)C=C3)C(C)=C2)CCC(F)(F)F)C=C1)=O
  • Chemical Name
    β-Alanine, N-[4-[(1S)-1-[[4'-(1,1-dimethylethyl)-2,6-dimethyl[1,1'-biphenyl]-4-yl]oxy]-4,4,4-trifluorobutyl]benzoyl]-

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Kelly RP, et al. Diabetes Obes Metab. 2015 Apr;17(4):414-22. 2. Grover S, et al. BMC Bioinformatics. 2014;15 Suppl 16:S13. 3. Kazda CM, et al. Diabetes Obes Metab. 2017 Aug;19(8):1071-1077.
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