Ac-IETD-pNA( ——— )

Catalog No. M41648 CAS No. 219138-21-3

Ac-Ile-Glu-Thr-Asp-pNA is a substrate for caspase-8.Caspase-8 binds to and cleaves the Ile-Glu-Thr-Asp (IETD) peptide sequence to release p-nitroalinide, which can be quantified by colorimetric detection at 405 nm as a measure of enzyme activity.

Purity : >98% (HPLC)

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

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Biological Information

Product Name

Ac-IETD-pNA
Note

Research use only, not for human use.
Brief Description

Ac-Ile-Glu-Thr-Asp-pNA is a substrate for caspase-8.Caspase-8 binds to and cleaves the Ile-Glu-Thr-Asp (IETD) peptide sequence to release p-nitroalinide, which can be quantified by colorimetric detection at 405 nm as a measure of enzyme activity.
Description

Ac-Ile-Glu-Thr-Asp-pNA is a substrate for caspase-8.Caspase-8 binds to and cleaves the Ile-Glu-Thr-Asp (IETD) peptide sequence to release p-nitroalinide, which can be quantified by colorimetric detection at 405 nm as a measure of enzyme activity.
In Vitro

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In Vivo

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Synonyms

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Pathway

Others
Target

Other Targets
Recptor

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Research Area

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Indication

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Chemical Information

CAS Number

219138-21-3
Formula Weight

638.6
Molecular Formula

C27H38N6O12
Purity

>98% (HPLC)
Solubility

H2O : 0.98 mg/mL (1.53 mM; adjust pH to 12 with 1 M NaOH)
SMILES

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Chemical Name

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Shipping & Storage Information

Storage

(-20℃)
Shipping

With Ice Pack
Stability

≥ 2 years

Reference

1. Smith GK, et al. Expression, preparation, and high-throughput screening of caspase-8: discovery of redox-based and steroid diacid inhibition. Arch Biochem Biophys. 2002;399(2):195-205.?

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