Cart
sales@molnova.com
Home - Products - Others - Other Targets - AZD5462

AZD5462

CAS No. 2787501-83-9

AZD5462( —— )

Catalog No. M35747 CAS No. 2787501-83-9

AZD5462 is a potent orally available relaxin receptor RXFP1 agonist for the study of heart failure and cancer.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
2MG 567 In Stock
5MG 850 In Stock
10MG 1207 In Stock
25MG 1822 In Stock
50MG 2558 In Stock
100MG 3168 In Stock
500MG Get Quote In Stock
1G Get Quote In Stock
Get Quotation Bulk Inquiry Add to Cart

Biological Information

  • Product Name
    AZD5462
  • Note
    Research use only, not for human use.
  • Brief Description
    AZD5462 is a potent orally available relaxin receptor RXFP1 agonist for the study of heart failure and cancer.
  • Description
    AZD5462 is a RXFP1 modulator, can be used for heart failure research. RXFP1 is the cognate receptor for human relaxin, belongs to GPCR family 1c number with anti-fibrotic and anti-inflammatory properties.
  • In Vitro
    AZD5462 (example 1) shows stimulatory activity on cAMP or cGMP production with EC50s of 17 nM and 50 nM, respectively.AZD5462 binds human plasma protein with fraction unbound (free) rate of 4.3%, and shows the stability with Clint values of 23 μL/min/mg (human licer microsomal), 4.8 μL/min/106 cells (human hepatocyte), and 11 μL/min/106 cells (rat hepatocyte).AZD5462 enhances phosphorylation of ERK with an EC50 value of 6.3 nM.
  • In Vivo
    ——
  • Synonyms
    ——
  • Pathway
    Others
  • Target
    Other Targets
  • Recptor
    RXFP receptor
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    2787501-83-9
  • Formula Weight
    544.65
  • Molecular Formula
    C30H41FN2O6
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    C(NCC1(C)CCC1)(=O)[C@@H]2[C@H](NC(=O)C3=C(OC)C=C(F)C(O[C@H]4CC[C@](C(O)=O)(C)CC4)=C3)[C@@]5(C[C@]2(CC5)[H])[H]
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Granberg Kenneth Lars, et al. 4-(2-Fluoro-4-methoxy-5-(3-(((1-methylcyclobutyl)methyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)phenoxy)-1-methylcyclohexane-1-carboxylic acid derivatives and similar compounds as RXFP1 modulators for the treatment of heart failure and their preparation: World Intellectual Property Organization, WO2022122773. 2022-06-16.
Calculator

Molecular Weight Calculator

Dilution Calculator

Molarity Calculator

molnova catalog
related products

  • Acitemate

    Acitemate(Chinoin 123) has an inhibitory effect on atherosclerosis and reduces the permeability of the aorta in rabbits fed a hyperlipidemic diet, which can be used to study atherosclerosis.

  • Glycinamide Hydrochl...

    Glycinamide Hydrochloride is a glycine pro-drug.

  • Psoralidin

    Psoralidin inhibits Akt phosphorylation and phosphatidylinositol 3-kinase activation and transcriptionally.

Sign In Join Free