AZD4747( —— )

Catalog No. M37231 CAS No. 2489226-14-2

AZD4747 is a selective and potent inhibitor of the mutant GTPase KRASG12C that crosses the blood-brain barrier and has potential antitumor activity for the study of pancreatic and colorectal adenocarcinoma.

Purity : >98% (HPLC)

COA

Datasheet

HNMR

HPLC

MSDS

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Biological Information

Product Name

AZD4747
Note

Research use only, not for human use.
Brief Description

AZD4747 is a selective and potent inhibitor of the mutant GTPase KRASG12C that crosses the blood-brain barrier and has potential antitumor activity for the study of pancreatic and colorectal adenocarcinoma.
Description

AZD4747 is a selective, blood-brain barrier-permeable mutant GTPase KRASG12C inhibitor. AZD4747 has the potential to study cancer.
In Vitro

——
In Vivo

——
Synonyms

——
Pathway

Others
Target

Other Targets
Recptor

Kras
Research Area

——
Indication

——

Chemical Information

CAS Number

2489226-14-2
Formula Weight

440.89
Molecular Formula

C24H22ClFN2O3
Purity

>98% (HPLC)
Solubility

In Vitro:?DMSO : 250 mg/mL (567.03 mM; Ultrasonic )
SMILES

O=C(C=C)N1CCN2CC3=CC(C#CC)=C(C(F)=C3OCC2C1)C=4C(Cl)=CC=CC4O
Chemical Name

——

Shipping & Storage Information

Storage

(-20℃)
Shipping

With Ice Pack
Stability

≥ 2 years

Reference

1. Kettle JG, et al. Discovery of AZD4747, a Potent and Selective Inhibitor of Mutant GTPase KRASG12C with Demonstrable CNS Penetration. J Med Chem. 2023 Jul 13;66(13):9147-9160.?

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