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Home - Products - GPCR/G Protein - Chemokine Receptor - AZD-4818

AZD-4818

CAS No. 1003566-93-5

AZD-4818( AZD4818 )

Catalog No. M10031 CAS No. 1003566-93-5

AZD-4818 is a highly potent, selective CCR1 antagonist with pIC50 of 8.6, inhibits chemotaxia of human monocytes to MIP-1α in a concentration-dependent manner.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    AZD-4818
  • Note
    Research use only, not for human use.
  • Brief Description
    AZD-4818 is a highly potent, selective CCR1 antagonist with pIC50 of 8.6, inhibits chemotaxia of human monocytes to MIP-1α in a concentration-dependent manner.
  • Description
    AZD-4818 is a highly potent, selective CCR1 antagonist with pIC50 of 8.6, inhibits chemotaxia of human monocytes to MIP-1α in a concentration-dependent manner; significantly reduces neutrophil influx and TNF-α levels on bronchoalveolar lavage (BAL) following intratracheal administration in vivo.COPD Phase 2 Discontinued.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    AZD4818
  • Pathway
    GPCR/G Protein
  • Target
    Chemokine Receptor
  • Recptor
    Chemokine Receptor
  • Research Area
    Inflammation/Immunology
  • Indication
    COPD

Chemical Information

  • CAS Number
    1003566-93-5
  • Formula Weight
    567.46
  • Molecular Formula
    C27H32Cl2N2O7
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 50 mg/mL (88.11 mM)
  • SMILES
    CC(C)(C(=O)O)Oc1cc(c(cc1Cl)C(=O)NC)OC[C@H](CN2CCC3(CC2)Cc4cc(ccc4O3)Cl)O
  • Chemical Name
    2-[2-Chloro-5-[(2S)-3-(5-chlorospiro[benzofuran-2(3H),4'-piperidin]-1'-yl)-2-hydroxypropoxy]-4-[(methylamino)carbonyl]phenoxy]-2-methylpropanoic acid

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Kerstjens HA, et al. Respir Med. 2010 Sep;104(9):1297-303. 2. Norman P. Expert Opin Ther Pat. 2009 Nov;19(11):1629-33. 3. Gilchrist A, et al. Br J Pharmacol. 2014 Nov;171(22):5127-38.
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