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AZ9482

CAS No. 1825345-33-2

AZ9482( —— )

Catalog No. M22949 CAS No. 1825345-33-2

AZ9482 is a selective and potent inhibitor of PARP featuring an amide linkage to a 2-piperazinyl-3-cyano-pyridine. AZ9482 exhibits very potent activity of centrosome declustering with EC50 of < 18 nM in HeLa cells.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    AZ9482
  • Note
    Research use only, not for human use.
  • Brief Description
    AZ9482 is a selective and potent inhibitor of PARP featuring an amide linkage to a 2-piperazinyl-3-cyano-pyridine. AZ9482 exhibits very potent activity of centrosome declustering with EC50 of < 18 nM in HeLa cells.
  • Description
    AZ9482 is a selective and potent inhibitor of PARP featuring an amide linkage to a 2-piperazinyl-3-cyano-pyridine. AZ9482 exhibits very potent activity of centrosome declustering with EC50 of < 18 nM in HeLa cells.
  • In Vitro
    AZ9482 exhibits an EC50 of 24 nM in MDA-MB-468 cells.AZ0108 treatment prevents CHK1 MARylation and induces hyperphosphorylation of CHK1, contributing to MPS formation and dysregulation of the cell cycle. Cell Viability Assay Cell Line:MDA-MB-468 cells.Concentration:0-10 μM.Incubation Time:3 days.Result:EC50 was 24 nM.
  • In Vivo
    AZ0108 also displays toxicity in vivo, the molecular basis of which is currently undefined, limiting pharmacological evaluation of AZ0108.
  • Synonyms
    ——
  • Pathway
    Cell Cycle/DNA Damage
  • Target
    PARP
  • Recptor
    PARP
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    1825345-33-2
  • Formula Weight
    450.5
  • Molecular Formula
    C26H22N6O2
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 125 mg/mL (277.48 mM)
  • SMILES
    O=C1NN=C(CC2=CC=CC(C(N3CCN(C4=NC=CC=C4C#N)CC3)=O)=C2)C5=CC=CC=C51
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Howard R T , Hemsley P , Petteruti P , et al. Structure-Guided Design and In-Cell Target Profiling of a Cell-Active Target Engagement Probe for PARP Inhibitors[J]. ACS Chemical Biology, 2020, XXXX(XXX).
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