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AZ13705339

CAS No. 2016806-57-6

AZ13705339( AZ-13705339 | AZ 13705339 )

Catalog No. M27853 CAS No. 2016806-57-6

AZ13705339 is a potent and selective PAK1 inhibitor with IC50 of 0.33 nM.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    AZ13705339
  • Note
    Research use only, not for human use.
  • Brief Description
    AZ13705339 is a potent and selective PAK1 inhibitor with IC50 of 0.33 nM.
  • Description
    AZ13705339 is a potent and selective PAK1 inhibitor with IC50 of 0.33 nM.(In Vitro):AZ13705339 (300 nM) prevents Siglec-8 binding-induced eosinophil death. In Namalwa cells, AZ13705339 (1 μM) inhibits αIgM-controlled but not PMA-induced adhesion.(In Vivo):In rats, AZ13705339 (100 mg/kg, p.o.) exhibits moderate clearance and Cmax of 7.7 μM.
  • In Vitro
    AZ13705339 (1 μM) inhibits αIgM-controlled adhesion and not PMA-induced adhesion in Namalwa cells.AZ13705339 (300 nM, 30 min) prevents Siglec-8 engagement-induced eosinophil death.
  • In Vivo
    AZ13705339 (100 mg/kg, P.O.) has moderate clearance and oral Cmax of 7.7 μM in rats.
  • Synonyms
    AZ-13705339 | AZ 13705339
  • Pathway
    Others
  • Target
    Other Targets
  • Recptor
    ——
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    2016806-57-6
  • Formula Weight
    629.76
  • Molecular Formula
    C33H36FN7O3S
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 250 mg/mL (396.98 mM)
  • SMILES
    CCS(=O)(=O)c1cc(Nc2ncc(F)c(n2)N(Cc2ccccc2C#N)c2cc(CO)ccc2C)ccc1N1CCN(C)CC1
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Andrew F Ducruet , et al. GM1485, a Nonimmunosuppressive Immunophilin Ligand, Promotes Neurofunctional Improvement and Neural Regeneration Following Stroke. J Neurosci Res. 2012 Jul;90(7):1413-23.
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