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AZ-32
CAS No. 2288709-96-4
AZ-32( —— )
Catalog No. M22388 CAS No. 2288709-96-4
AZ32 is an orally bioavailable and blood-brain barrier-penetrating inhibitor of ATM(IC50 of <6.2 nM and 0.31 μM for ATM enzyme and in cell).
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 67 | In Stock |
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| 5MG | 110 | In Stock |
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| 10MG | 177 | In Stock |
|
| 25MG | 312 | In Stock |
|
| 50MG | 488 | In Stock |
|
| 100MG | 704 | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameAZ-32
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NoteResearch use only, not for human use.
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Brief DescriptionAZ32 is an orally bioavailable and blood-brain barrier-penetrating inhibitor of ATM(IC50 of <6.2 nM and 0.31 μM for ATM enzyme and in cell).
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DescriptionAZ32 is an orally bioavailable and blood-brain barrier-penetrating inhibitor of ATM(IC50 of <6.2 nM and 0.31 μM for ATM enzyme and in cell)
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In VitroAZ32 is a next-generation blood-brain barrier (BBB)-penetrating ATM inhibitor. AZ32 blocks the DNA damage response and radiosensitized GBM cells in vitro.
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In VivoAZ32, with enhanced BBB penetration, is highly efficient in vivo as radiosensitizer in syngeneic and human, orthotopic mouse glioma model compared with AZ31. AZ32 is a specific inhibitor of the ATM kinase that possesses good BBB penetration in mouse. Following a single oral dose of AZ32 (200 mg/kg) in mice, the free-brain concentrations of AZ32 are in excess of the cellular IC50 for approximately 22 hours.
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Synonyms——
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PathwayCell Cycle/DNA Damage
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TargetATM/ATR
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RecptorATM
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Research Area——
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Indication——
Chemical Information
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CAS Number2288709-96-4
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Formula Weight328.37
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Molecular FormulaC20H16N4O
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Purity>98% (HPLC)
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SolubilityDMSO:150 mg/mL?(456.80 mM)
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SMILESCNC(=O)c1ccc(cc1)c2cnc3cnc(cn23)c4ccccc4
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Karlin J, et al. Orally Bioavailable and Blood-Brain Barrier-Penetrating ATM Inhibitor (AZ32) Radiosensitizes Intracranial Gliomas in Mice. Mol Cancer Ther. 2018 Aug;17(8):1637-1647.
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