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AX20017

CAS No. 329221-38-7

AX20017( —— )

Catalog No. M20738 CAS No. 329221-38-7

AX20017 is a small-molecule protein kinase G (PknG) inhibitor(IC50 : 0.39 μM). It acts by blocking the proliferation of M. tuberculosis.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    AX20017
  • Note
    Research use only, not for human use.
  • Brief Description
    AX20017 is a small-molecule protein kinase G (PknG) inhibitor(IC50 : 0.39 μM). It acts by blocking the proliferation of M. tuberculosis.
  • Description
    AX20017 is a small-molecule protein kinase G (PknG) inhibitor(IC50 : 0.39 μM). It acts by blocking the proliferation of M. tuberculosis.(In Vitro):The compound AX20017 inhibitor is bound deep within a narrow pocket formed by the inter lobe cleft of the PknG domain. The main chain Glu233:O and Val235:NH of PknG form hydrogen bonds with AX20017.AX20017 results in mycobacterial transfer to lysosomes and killing of the mycobacteria. AX20017 does not affect the human kinases, whereas the activity of PknG is effectively inhibited. AX20017 does not affect cellular morphology, membrane ruffling, or macropinocytosis.
  • In Vitro
    The compound AX20017 inhibitor is bound deep within a narrow pocket formed by the inter lobe cleft of the PknG domain. The main chain Glu233:O and Val235:NH of PknG form hydrogen bonds with AX20017.AX20017 results in mycobacterial transfer to lysosomes and killing of the mycobacteria. AX20017 does not affect the human kinases, whereas the activity of PknG is effectively inhibited. AX20017 does not affect cellular morphology, membrane ruffling, or macropinocytosis.
  • In Vivo
    ——
  • Synonyms
    ——
  • Pathway
    Others
  • Target
    Other Targets
  • Recptor
    PknG
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    329221-38-7
  • Formula Weight
    264.34
  • Molecular Formula
    C13H16N2O2S
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO:32 mg/mL (121.06 mM)
  • SMILES
    NC(=O)c1c(NC(=O)C2CC2)sc2CCCCc12
  • Chemical Name
    2-(Cyclopropanecarbonylamino)-233a45677a-octahydro-1-benzothiophene-3-carboxamide

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Scherr N Honnappa S Kunz G et al. Structural basis for the specific inhibition of protein kinase G a virulence factor of Mycobacterium tuberculosis[J]. Proceedings of the National Academy of Sciences 2007 104(29):12151-12156.
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