AUTAC1( —— )

Catalog No. M36576 CAS No. 2241669-09-8

COA

Datasheet

HNMR

HPLC

MSDS

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Product Name

AUTAC1
Note

Research use only, not for human use.
Brief Description

AUTAC1 is a MetAP2-targeted autophagy-mediated degrader (AUTAC) with potential anticancer activity that degrades MetAP2 and FKBP12 proteins and can be used to synthesize PROTAC.
Description

AUTAC1 is a MetAP2-targeting autophagy-mediated degrader (AUTAC). AUTACs contain a degradation tag and a warhead to provide target specificity. AUTAC1 contains an FBnG (p-Fluorobenzyl Guanine) and a Fumagillol moiety. Fumagillol binds covalently to MetAP2.
In Vitro

AUTAC1 (1-100 μM, 24 h) silences endogenous MetAP2 in hela cells..Western Blot Analysis Cell Line:HeLa cells.Concentration:1-100 μM.Incubation Time:24 h.Result:Silenced endogenous MetAP2.
In Vivo

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Synonyms

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Pathway

Others
Target

Other Targets
Recptor

AUTACs
Research Area

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Indication

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CAS Number

2241669-09-8
Formula Weight

931.08
Molecular Formula

C44H63FN8O11S
Purity

>98% (HPLC)
Solubility

In Vitro:?DMSO : 100 mg/mL (107.40 mM; Ultrasonic )
SMILES

C[C@@]1([C@@]2([C@@]3(CO3)CC[C@@H](OC(NCCCOCCOCCOCCCNC([C@H](CSC=4N(CC5=CC=C(F)C=C5)C6=C(N4)C(=O)N=C(N)N6)NC(C)=O)=O)=O)[C@H]2OC)[H])[C@H](CC=C(C)C)O1
Chemical Name

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1. Daiki Takahashi, et al. AUTACs: Cargo-Specific Degraders Using Selective Autophagy. Mol Cell. 2019 Dec 5;76(5):797-810.e10.?

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