AS-8351( AS8351 | NSC 51355 )

Catalog No. M15984 CAS No. 796-42-9

COA

Datasheet

HNMR

HPLC

MSDS

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Product Name

AS-8351
Note

Research use only, not for human use.
Brief Description

AS-8351 (NSC 51355) is a small molecule that induces reprogramming of human fetal lung fibroblasts into functional cardiomyocytes.
Description

AS-8351 (NSC 51355) is a small molecule that induces reprogramming of human fetal lung fibroblasts into functional cardiomyocytes, in combination with CHIR 99021, A83-01, BIX 01294, SC1, Y-27632, OAC2, SU 16f and JNJ 10198409; competes with α-ketoglutarate (α-KG) for chelating iron/Fe(II) in certain epi-genetic enzymes, such as the JmjC-domain-containing histone demethylases (JmjC-KDMs) that require α-KG and iron as co-factors.(In Vitro):AS8351 affects epigenetic modifications by competing with α-ketoglutarate (α-KG) for chelating iron [Fe(II)] in certain epigenetic enzymes, such as the JmjC domain-containing histone demethylases (JmjC-KDMs) that require α-KG and iron as co-factors.
In Vitro

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In Vivo

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Synonyms

AS8351 | NSC 51355
Pathway

Chromatin/Epigenetic
Target

Histone Demethylase
Recptor

Demethylase
Research Area

Other Indications
Indication

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CAS Number

796-42-9
Formula Weight

291.31
Molecular Formula

C17H13N3O2
Purity

>98% (HPLC)
Solubility

DMSO: 29.1 mg/mL (100 mM) （ < 1 mg/ml refers to the product slightly soluble or insoluble )
SMILES

OC1=CC=C2C=CC=CC2=C1/C=N/NC(C3=CC=NC=C3)=O
Chemical Name

2-Hydroxy-1-naphthaldehyde isonicotinoylhydrazone

1. Cao N, et al. Science. 2016 Jun 3;352(6290):1216-20.

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