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AN12855
CAS No. ——
AN12855( AN-12855 | AN 12855 )
Catalog No. M17107 CAS No. ——
AN12855 (AN-12855) is potent, cofactor-independent M. tuberculosis InhA inhibitor, binds to and inhibits InhA with IC50 of 0.03 uM.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 100MG | Get Quote | Get Quote |
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| 200MG | Get Quote | Get Quote |
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| 500MG | Get Quote | Get Quote |
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| 1G | Get Quote | Get Quote |
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Biological Information
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Product NameAN12855
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NoteResearch use only, not for human use.
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Brief DescriptionAN12855 (AN-12855) is potent, cofactor-independent M. tuberculosis InhA inhibitor, binds to and inhibits InhA with IC50 of 0.03 uM.
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DescriptionAN12855 (AN-12855) is potent, cofactor-independent M. tuberculosis InhA inhibitor, binds to and inhibits InhA with IC50 of 0.03 uM, shows potent activity against whole-cell M. tuberculosis H37Rv with IC90 of 0.09 uM; AN12855 demonstrates potent activity against drug-susceptible and drug-resistant strains of M. tuberculosis, exhibits comparable efficacy to the frontline antitubercular drug isoniazid (INH) in both acute and chronic models of TB infection with a lower potential for resistance development and shows in vitro activity against conventional KatG-mediated INH-resistant M. tuberculosis.
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In Vitro——
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In Vivo——
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SynonymsAN-12855 | AN 12855
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PathwayGPCR/G Protein
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TargetAntibacterial
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RecptorAntibacterial
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Research Area——
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Indication——
Chemical Information
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CAS Number——
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Formula Weight441.188
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Molecular FormulaC17H15BF3N3O5S
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Purity>98% (HPLC)
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Solubility——
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SMILES——
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Chemical Name(E)-2-((2-(ethylsulfonyl)-1-hydroxy-1,2-dihydrobenzo[d][1,2,3]diazaborinin-7-yl)oxy)-5-(trifluoromethyl)benzaldehyde oxime
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Xia Y, et al. Life Sci Alliance. 2018 Jun 1;1(3):e201800025.
2. Robertson GT, et al. Antimicrob Agents Chemother. 2019 Mar 27;63(4). pii: e02071-18.
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