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AIMP2-DX2-IN-1
CAS No. 848256-17-7
AIMP2-DX2-IN-1( —— )
Catalog No. M35543 CAS No. 848256-17-7
AIMP2-DX2-IN-1 is a potent AIMP2-DX2 inhibitor with potential antitumor activity for the study of lymphoma.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 119 | In Stock |
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| 5MG | 179 | In Stock |
|
| 10MG | 282 | In Stock |
|
| 25MG | 477 | In Stock |
|
| 50MG | 679 | In Stock |
|
| 100MG | 888 | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameAIMP2-DX2-IN-1
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NoteResearch use only, not for human use.
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Brief DescriptionAIMP2-DX2-IN-1 is a potent AIMP2-DX2 inhibitor with potential antitumor activity for the study of lymphoma.
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DescriptionAIMP2-DX2-IN-1 (Compound 35) is a potent AIMP2-DX2 inhibitor with an IC50 of 0.1063 μM.
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In VitroAIMP2-DX2-IN-1 (Compound 35) (0-1 μM, 96 h) shows inhibitory activity against A549 and H460 cells without toxicity for normal cells.AIMP2-DX2-IN-1 showes very poor metabolic stability and good plasma stability in both human and mouse, and CYP inhibition need to be improved.Cell Viability Assay Cell Line:A549, H460 and WI-26 Concentration:0-1 μM Incubation Time:96 h Result:Showed inhibitory activities with EC50s of 0.690 ± 0.648 μM and 0.150 ± 0.062 μM against A549 and H460 cells, respectively. And is not active for WI-26.
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In Vivo——
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Synonyms——
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PathwayOthers
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TargetOther Targets
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RecptorOthers
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Research Area——
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Indication——
Chemical Information
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CAS Number848256-17-7
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Formula Weight359.42
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Molecular FormulaC23H21NO3
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Purity>98% (HPLC)
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Solubility——
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SMILESC(NC(CC1=CC=C(C=C1)C2=CC=CC=C2)=O)C3OC=4C(OC3)=CC=CC4
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Lee B, et al. Discovery of benzodioxane analogues as lead candidates of AIMP2-DX2 inhibitors. Bioorg Med Chem Lett. 2022 Jul 13;73:128889.?
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