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AIMP2-DX2-IN-1

CAS No. 848256-17-7

AIMP2-DX2-IN-1( —— )

Catalog No. M35543 CAS No. 848256-17-7

AIMP2-DX2-IN-1 is a potent AIMP2-DX2 inhibitor with potential antitumor activity for the study of lymphoma.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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5MG 179 In Stock
10MG 282 In Stock
25MG 477 In Stock
50MG 679 In Stock
100MG 888 In Stock
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Biological Information

  • Product Name
    AIMP2-DX2-IN-1
  • Note
    Research use only, not for human use.
  • Brief Description
    AIMP2-DX2-IN-1 is a potent AIMP2-DX2 inhibitor with potential antitumor activity for the study of lymphoma.
  • Description
    AIMP2-DX2-IN-1 (Compound 35) is a potent AIMP2-DX2 inhibitor with an IC50 of 0.1063 μM.
  • In Vitro
    AIMP2-DX2-IN-1 (Compound 35) (0-1 μM, 96 h) shows inhibitory activity against A549 and H460 cells without toxicity for normal cells.AIMP2-DX2-IN-1 showes very poor metabolic stability and good plasma stability in both human and mouse, and CYP inhibition need to be improved.Cell Viability Assay Cell Line:A549, H460 and WI-26 Concentration:0-1 μM Incubation Time:96 h Result:Showed inhibitory activities with EC50s of 0.690 ± 0.648 μM and 0.150 ± 0.062 μM against A549 and H460 cells, respectively. And is not active for WI-26.
  • In Vivo
    ——
  • Synonyms
    ——
  • Pathway
    Others
  • Target
    Other Targets
  • Recptor
    Others
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    848256-17-7
  • Formula Weight
    359.42
  • Molecular Formula
    C23H21NO3
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    C(NC(CC1=CC=C(C=C1)C2=CC=CC=C2)=O)C3OC=4C(OC3)=CC=CC4
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Lee B, et al. Discovery of benzodioxane analogues as lead candidates of AIMP2-DX2 inhibitors. Bioorg Med Chem Lett. 2022 Jul 13;73:128889.?
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