AGN192836( AGN 192836 )

Catalog No. M12609 CAS No. 171102-29-7

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Datasheet

HNMR

HPLC

MSDS

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Product Name

AGN192836
Note

Research use only, not for human use.
Brief Description

AGN192836 (AGN 192836) is a potent, selective α2 adrenergic (alpha 2-adrenoceptor) agonist with EC50 of 8.7, 41 and 6.6 nM for α2A, α2B and α2C receptor, respectively.
Description

AGN192836 (AGN 192836) is a potent, selective α2 adrenergic (alpha 2-adrenoceptor) agonist with EC50 of 8.7, 41 and 6.6 nM for α2A, α2B and α2C receptor, respectively; displays 1200-, 50- and 10-fols selectivity for the α2A-receptor, α2B-receptor, and α2C-receptors relative to the α2C-receptors; demonstrates effectivity for the reduction of intraocular pressure and for the reduction of blood pressure in vivo.
In Vitro

Binding assays demonstrates that AGN 192836 is 1200-fold selective for the α2A-receptor relative to the α1-receptor, 50-fold selective for the α2A-receptor relative to the α2B-receptor, and 10-fold selective for the α2Areceptor relative to the α2C-receptor.
In Vivo

AGN 192836 is equally efficacious when compared to brimonidine for the reduction of intraocular pressure upon topical administration to the rabbit and more efficacious than brimonidine for the reduction of blood pressure upon intravenous administration to monkey.
Synonyms

AGN 192836
Pathway

Angiogenesis
Target

Adrenergic Receptor
Recptor

Adrenergic Receptor
Research Area

Cardiovascular Disease
Indication

——

CAS Number

171102-29-7
Formula Weight

231.255
Molecular Formula

C12H13N3O2
Purity

>98% (HPLC)
Solubility

In Vitro:?DMSO : 80 mg/mL (345.95 mM)
SMILES

CC1=C(C=CC2=C1OCCO2)NC3=NC=CN3
Chemical Name

N-(2,3-Dihydro-5-methyl-1,4-benzodioxin-6-yl)-1H-imidazol-2-amine

1. Munk SA, et al. J Med Chem. 1997 Jan 3;40(1):18-23.

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