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AG-1295

CAS No. 71897-07-9

AG-1295( NSC 380341 | Tyrphostin AG 1295 )

Catalog No. M15750 CAS No. 71897-07-9

A quinoxaline-type tyrphostin that acts as a potent and selective inhibitor of PDGFR kinase in vitro and in Swiss 3T3 cells with IC50 of 0.3-1 uM.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    AG-1295
  • Note
    Research use only, not for human use.
  • Brief Description
    A quinoxaline-type tyrphostin that acts as a potent and selective inhibitor of PDGFR kinase in vitro and in Swiss 3T3 cells with IC50 of 0.3-1 uM.
  • Description
    A quinoxaline-type tyrphostin that acts as a potent and selective inhibitor of PDGFR kinase in vitro and in Swiss 3T3 cells with IC50 of 0.3-1 uM; inhibits PDGF-stimulated DNA synthesis with IC50 of 2.5 uM without affecting activity of EGFR; selectively attenuates smooth muscle cell growth in vitro and reduces neointimal formation after balloon angioplasty in swine.Blood Cancer Discontinued.
  • In Vitro
    Cell Viability Assay Cell Line:Rabbit conjunctival fibroblasts cells Concentration:1 μM, 10 μM, 100 μM Incubation Time:3 days Result:Inhibited rabbit conjunctival fibroblast cell growth stimulated by PDGF-AA or PDGF-BB.
  • In Vivo
    Animal Model:Sprague-Dawley rats (240-270 g)Dosage:12 mg/kg Administration:Intraperitoneal injection; daily; for 14 or 21 days Result:Attenuated interstitial fibrosis in rat kidney after unilateral obstruction.
  • Synonyms
    NSC 380341 | Tyrphostin AG 1295
  • Pathway
    Angiogenesis
  • Target
    PDGFR
  • Recptor
    PDGFR
  • Research Area
    Cancer
  • Indication
    Blood cancer

Chemical Information

  • CAS Number
    71897-07-9
  • Formula Weight
    234.3
  • Molecular Formula
    C16H14N2
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 50 mg/mL (213.40 mM)
  • SMILES
    CC1=C(C)C=C2N=CC(C3=CC=CC=C3)=NC2=C1
  • Chemical Name
    6,7-dimethyl-2-phenyl-quinoxaline

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Kovalenko M, et al. Cancer Res. 1994 Dec 1;54(23):6106-14. 2. Banai S, et al. Circulation. 1998 May 19;97(19):1960-9. 3. Iwamoto H, et al. J Lab Clin Med. 2000 May;135(5):406-12. 4. Karck M, et al. Transplantation. 2002 Nov 15;74(9):1335-41.
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