7-Epitaxol
CAS No. 105454-04-4
7-Epitaxol( 7-epi-Paclitaxel )
Catalog No. M17784 CAS No. 105454-04-4
7-Epitaxol is the major derivative of taxol found in cells and that its presence does not alter, in a major way, the overall biological activity of taxol.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
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Biological Information
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Product Name7-Epitaxol
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NoteResearch use only, not for human use.
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Brief Description7-Epitaxol is the major derivative of taxol found in cells and that its presence does not alter, in a major way, the overall biological activity of taxol.
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Description7-Epitaxol is the major derivative of taxol found in cells and that its presence does not alter, in a major way, the overall biological activity of taxol.(In Vitro):7-epi-Taxol (7-Epitaxol) is a metabolite of taxol. 7-epi-Taxol has activity comparable to that of taxol on cell replication, microtubule bundle formation and in vitro microtubule polymerization.
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In Vitro7-epi-Taxol (7-Epitaxol) is a metabolite of taxol. 7-epi-Taxol has activity comparable to that of taxol on cell replication, microtubule bundle formation and in vitro microtubule polymerization.
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In Vivo——
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Synonyms7-epi-Paclitaxel
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PathwayCell Cycle/DNA Damage
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TargetTopoisomerase
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RecptorOthers
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Research AreaCancer
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Indication——
Chemical Information
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CAS Number105454-04-4
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Formula Weight853.91
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Molecular FormulaC47H51NO14
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Purity>98% (HPLC)
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SolubilityDMSO : ≥ 106.6 mg/mL; 124.84 mM
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SMILESCC1=C2C(C(=O)C3(C(CC4C(C3C(C(C2(C)C)(CC1OC(=O)C(C(C5=CC=CC=C5)NC(=O)C6=CC=CC=C6)O)O)OC(=O)C7=CC=CC=C7)(CO4)OC(=O)C)O)C)OC(=O)C
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
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α-Lapachone
alpha-Lapachone has antineoplastic activity, it shows an approximately trypanocidal activity against Trypanosoma cruzi.
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Exatecan Mesylate
Exatecan Mesylate is a DNA topoisomerase I inhibitor (IC50: 2.2 μM, 0.975 μg/mL).Exatecan Mesylate (DX-8951f) significantly inhibits the proliferation of several cancer cell lines, with mean GI50s of 2.02 ng/mL, 2.92 ng/mL, 1.53 ng/mL, and 0.877 ng/mL for breast cancer cells, colon cancer cells, stomach cancer cells and lung cancer cells, respectively.
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DRF-1042
DRF-1042, an orally active camptothecin analog, exhibits anticancer and insecticidal activities by inhibiting DNA topoisomerase I. It has been studied for its efficacy against solid tumors, including prostate and colon cancers.
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