5-Nitro-110-phenanthroline

Research use only, not for human use.

5-Nitro-110-phenanthroline(5-NP) is a potent bactericidal agent and inhibiting Clostridium difficile.

5-Nitro-110-phenanthroline(5-NP) is a potent bactericidal agent and inhibiting Clostridium difficile.

5-Nitro-1,10-phenanthroline (25 μM; 24 h) kills naturally resistant intracellular bacteria by inducing autophagy in THP-1 macrophages. 5-Nitro-1,10-phenanthroline (1x, 5x, 20x or 50x MIC, MIC=0.78 μM; 1 h) also modulates the host machinery to kill intracellular pathogens by inhibiting mycolic acid biosynthesis of Mtb. Cell Viability Assay Cell Line:Mtb H37Rv, M. bovis BCG and M. bovis BCG-5NP resistant strain Concentration:0-12.5 μM Incubation Time:24 hours Result:Inhibited pathogens with MIC99 values of 0.78 μM (Mtb H37Rv), 0.78 μM (M. bovis BCG), and >12.5 μM (M. bovis BCG-5NP), respectively.

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5-NP

GPCR/G Protein

Antibacterial

Bacterial

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4199-88-6

225.2

C12H7N3O2

>98% (HPLC)

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O=[N+]([O-])c1cc2cccnc2c2ncccc12

5-Nitro-110-phenanthroline

(-20℃)

With Ice Pack

≥ 2 years