4u8C( IRE1 Inhibitor III )

Catalog No. M11667 CAS No. 14003-96-4

COA

Datasheet

HNMR

HPLC

MSDS

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Product Name

4u8C
Note

Research use only, not for human use.
Brief Description

4μ8C is a potent and selective IRE1 Rnase inhibitor with IC50 of 76 nM.
Description

4μ8C is a potent and selective IRE1 Rnase inhibitor with IC50 of 76 nM.
In Vitro

——
In Vivo

Animal Model:ApoE-/- mice Dosage:10 mg/kg Administration:I.p. injection; daily; for 4 more weeks Result:Led to a significant reduction (45.2%) in atherosclerotic lesion area in en face aorta preparations.
Synonyms

IRE1 Inhibitor III
Pathway

Others
Target

Other Targets
Recptor

IRE1 RN/Ase
Research Area

Other Indications
Indication

——

CAS Number

14003-96-4
Formula Weight

204.18
Molecular Formula

C11H8O4
Purity

>98% (HPLC)
Solubility

DMSO:19 mg/mL (93.05 mM); Ethanol:<1 mg/mL (<1 mM); Water:<1 mg/mL (<1 mM)
SMILES

O=CC1=C(O2)C(C(C)=CC2=O)=CC=C1O
Chemical Name

7-hydroxy-4-methyl-2-oxo-2H-1-benzopyran-8-carboxaldehyde

1. Cross BC, et al. Proc natl Acad Sci U S A. 2012, 109(15), E869-878.

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