4-Methylpyrazole( 4-Methylpyrazole )

Catalog No. M15874 CAS No. 7554-65-6

COA

Datasheet

HNMR

HPLC

MSDS

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Product Name

4-Methylpyrazole
Note

Research use only, not for human use.
Brief Description

Fomepizole is used as an antidote in confirmed or suspected methanol or ethylene glycol poisoning.
Description

Fomepizole is used as an antidote in confirmed or suspected methanol or ethylene glycol poisoning. Fomepizole is a competitive inhibitor of alcohol dehydrogenase, the enzyme that catalyzes the initial steps in the metabolism of ethylene glycol and methanol to their toxic metabolites. (In Vivo):Pretreatment with Fomepizole (4-Methylpyrazole; 25 mg/kg; IP) prolongs ethanol neurobehavioral toxicity in CD-1 mice.
In Vitro

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In Vivo

Pretreatment with Fomepizole (4-Methylpyrazole; 25 mg/kg; IP) prolongs ethanol neurobehavioral toxicity in CD-1 mice Animal Model:Male CD-1 mice weighing 18-25 gDosage:25 mg/kg Administration:IP; single dose Result:Decreased the dose of ethanol (1-5 g/kg; IP) at which 50% of the animals failed a particular outcome test (toxic dose 50; TD50).
Synonyms

4-Methylpyrazole
Pathway

Endocrinology/Hormones
Target

AChR
Recptor

ADH| CAT
Research Area

Other Indications
Indication

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1.Nagata H, et al. Am J Physiol. 1996 Dec;271(6 Pt 1):G1028-33.

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