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4-Demethyldeoxypodophyllotoxin
CAS No. 3590-93-0
4-Demethyldeoxypodophyllotoxin( —— )
Catalog No. M37321 CAS No. 3590-93-0
4-Demethyldeoxypodophyllotoxin, an aryl tetrahydronaphthalenyl lignan analog from the roots of Podophyllum peltatum, has anticancer activity and modulates the Chk-2 signaling pathway in MCF-7 breast cancer cells.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 185 | Get Quote |
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| 5MG | 282 | Get Quote |
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| 10MG | 464 | Get Quote |
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| 25MG | 720 | Get Quote |
|
| 50MG | 975 | Get Quote |
|
| 500MG | Get Quote | Get Quote |
|
| 1G | Get Quote | Get Quote |
|
Biological Information
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Product Name4-Demethyldeoxypodophyllotoxin
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NoteResearch use only, not for human use.
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Brief Description4-Demethyldeoxypodophyllotoxin, an aryl tetrahydronaphthalenyl lignan analog from the roots of Podophyllum peltatum, has anticancer activity and modulates the Chk-2 signaling pathway in MCF-7 breast cancer cells.
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Description4-Demethyldeoxypodophyllotoxin is an aryltetralin lignan that can be found in Podophyllum peltatum.
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In Vitro——
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In Vivo——
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Synonyms——
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PathwayAngiogenesis
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TargetChk
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RecptorChk
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Research Area——
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Indication——
Chemical Information
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CAS Number3590-93-0
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Formula Weight384.38
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Molecular FormulaC21H20O7
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Purity>98% (HPLC)
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Solubility——
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SMILESO=C1[C@@]2([C@@H](C=3C(C[C@]2(CO1)[H])=CC4=C(C3)OCO4)C5=CC(OC)=C(O)C(OC)=C5)[H]
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
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CCT-245737
A highly potent, selective, ATP-competitive inhibitor of Chk1 with IC50 of 1.3 nM; weak inhibition on Chk2 (IC50=2440 nM).
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CCT241533
A potent and selective ATP-competitive inhibitor of CHK2 K5777:N5777with IC50 of 3 nM.
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SAR-020106
SAR-020106 is a potent, ATP-competitive, and selective CHK1 inhibitor with an IC50 of 13.3 nmol/L on the isolated human enzyme.SAR-020106 is an ATP-competitive, potent, and selective CHK1 inhibitor with an IC(50) of 13.3 nmol/L on the isolated human enzyme. This compound abrogates an etoposide-induced G(2) arrest with an IC(50) of 55 nmol/L in HT29 cells, and significantly enhances the cell killing of gemcitabine and SN38 by 3.0- to 29-fold in several colon tumor lines in vitro and in a p53-dependent fashion.
