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2OH-BNPP1

CAS No. 833481-73-5

2OH-BNPP1( —— )

Catalog No. M24823 CAS No. 833481-73-5

2OH-BNPP1 is a BUB1 kinase, a Ser/Thr kinase inhibitor, it used for the treatment of cancer.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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10MG 255 In Stock
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Biological Information

  • Product Name
    2OH-BNPP1
  • Note
    Research use only, not for human use.
  • Brief Description
    2OH-BNPP1 is a BUB1 kinase, a Ser/Thr kinase inhibitor, it used for the treatment of cancer.
  • Description
    2OH-BNPP1 is a BUB1 kinase, a Ser/Thr kinase inhibitor, it used for the treatment of cancer.
  • In Vitro
    2OH-BNPP1 (0.1-50 μM) abrogates TGFβ signaling in a dose dependent manner. 2OH-BNPP1 dose-dependently impairs the TGFβ-induced phosphorylation of proteins that mediate canonical and non-canonical TGFβ signaling in multiple cancer cell lines and normal cell lines.
  • In Vivo
    2OH-BNPP1 (50 mg/kg) blocks TGFβ signaling in vivo, and significantly decreases abundance of phosphorylated SMAD2 in tumor-bearing mice.
  • Synonyms
    ——
  • Pathway
    Others
  • Target
    Other Targets
  • Recptor
    BUB1 kinase
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    833481-73-5
  • Formula Weight
    297.35
  • Molecular Formula
    C16H19N5O
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO: 100 mg/mL (336.30 mM)
  • SMILES
    CC(C)(C)n1nc(Cc(cccc2)c2O)c2c(N)ncnc12
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Nyati S, et al. The kinase activity of the Ser/Thr kinase BUB1 promotes TGF-β signaling. Sci Signal. 2015 Jan 6;8(358):ra1.
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